Changes

===Etorphine===

===Etorphine===

Etorphine is a hugely potent opioid that is a component of large animal and small animal immobilon. (Large animal immobilon consists of etorphine plus [[Phenothiazines#Acepromazine|acepromazine]]; small animal immobilon comprises etorphine and [[Phenothiazines#Methotrimeprazine|methotrimeprazine]] ). It may be fatal to man follwing self administration, wehn opioid antagonism with [[#Opioid Antagonists|naloxone]] is required.

Etorphine is a hugely potent opioid that is a component of large animal and small animal immobilon. (Large animal immobilon consists of etorphine plus [[Phenothiazines#Acepromazine|acepromazine]]; small animal immobilon comprises etorphine and [[Phenothiazines#Methotrimeprazine|methotrimeprazine]] ). It may be fatal to man following self administration, when opioid antagonism with [[#Opioid Antagonists|naloxone]] is required.

==Opioid Antagonists==

==Opioid Antagonists==

Naloxone is an antagonist to endogenous opioids. It is frequently used in human medicine to antagonise opioid narcotics in the incidence of overdose. Naloxone may be administered intravenously, intramuscularly, intrathecally or subcutaneously. It has a short duration of action (1-2 hours) and so repeated administrations may be necessary.

Naloxone is an antagonist to endogenous opioids. It is frequently used in human medicine to antagonise opioid narcotics in the incidence of overdose. Naloxone may be administered intravenously, intramuscularly, intrathecally or subcutaneously. It has a short duration of action (1-2 hours) and so repeated administrations may be necessary.