Changes

*** '''Eosinophils''': kill parasites by the release of granules

*** '''Eosinophils''': kill parasites by the release of granules

*** '''Basophils/ mast cells''': kill parasites by the release of granules

*** '''Basophils/ mast cells''': kill parasites by the release of granules

** Blood '''[[Monocytes - WikiBlood]]''': phagocytose bacteria

** Blood '''[[[[Monocytes - WikiBlood|monocytes]]]]''': phagocytose bacteria

** Tissue mast cells and '''macrophages''': phagocytose bacteria

** Tissue mast cells and '''macrophages''': phagocytose bacteria

*Effectively, innate cellular response seeks to hold off the infection until the [[Adaptive Immune System - WikiBlood|adaptive]] response can back it up with a more specific attack

*Effectively, innate cellular response seeks to hold off the infection until the [[Adaptive Immune System - WikiBlood|adaptive]] response can back it up with a more specific attack

** CNS microglia

** CNS microglia

** Sinus-lining macrophages of the lymph nodes and spleen

** Sinus-lining macrophages of the lymph nodes and spleen

* [[Monocytes - WikiBlood|'''Monocytes''']] (immature macrophages) are circulating phagocytes

* [[[[Monocytes - WikiBlood|monocytes]]|'''Monocytes''']] (immature macrophages) are circulating phagocytes

** Circulate for 6-8 hours  

** Circulate for 6-8 hours  

** Can function as phagocytes within the blood and as newly migrated cells in tissues

** Can function as phagocytes within the blood and as newly migrated cells in tissues

* Neutrophils produce vasoactive peptides

* Neutrophils produce vasoactive peptides

** E.g. histamine and bradykinin

** E.g. histamine and bradykinin

** Cause a great increase in extravasation of blood granulocytes and [[Monocytes - WikiBlood]] and plasma proteins at the site of infection

** Cause a great increase in extravasation of blood granulocytes and [[[[Monocytes - WikiBlood|monocytes]]]] and plasma proteins at the site of infection

* Neutrophils are the archetypal cell associated with [[Inflammation - WikiBlood|acute inflammation]]

* Neutrophils are the archetypal cell associated with [[Inflammation - WikiBlood|acute inflammation]]

** Are attracted to sites of inflammation by:

** Are attracted to sites of inflammation by: