Difference between revisions of "Neospora"

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***Post-natal infection occurs but is less common
 
***Post-natal infection occurs but is less common
  
*''Neospora caninum'' in [[Parasitic Myositis#Protozoa|myositis]]
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*''Neospora caninum'' in [[Muscles Inflammatory - Pathology#Protozoa|myositis]]
  
  
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</big>
 
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*''N. caninum''
 
**Necrotising inflammation of muscles
 
**Myositis more severe than in toxoplasmosis
 
 
''N. caninum'' - A disease of cattle with late abortion of mummified or autolysed foetus. May also get foetal malformation, e.g. arthrogryposis.
 
 
==Test yourself with the Tissue Cyst Forming Coccidian Flashcards==
 
 
[[Tissue_Cyst_Forming_Coccidian_Flashcards|Tissue Cyst Forming Coccidian Flashcards]]
 
  
 
[[Category:Tissue Cyst Forming Coccidia]]
 
[[Category:Tissue Cyst Forming Coccidia]]
 
[[Category:To_Do_-_Parasites]]
 

Revision as of 22:50, 9 April 2010

  • 2 main species
    • Neospora caninum in the dog
    • Neospora hughesi in the horse
  • Sporulated oocysts measuring just 10μm
  • Oocyst contains 2 sporocysts with 4 sporozoites
  • Route of transmission not fully understood
  • Often misdiagnosed as Toxoplasma gondii
    • Sarcocystis cysts have thicker walls
  • Infection diagnosed by IFAT, ELISA or PCR
    • Identification of lesions and organisms in tissue using immunohistochemical staining
    • Eliminate other causes of abortion first

Life cycle

  • Life cycle similar to Toxoplasma gondii
  • Limited range of warm-blooded intermediate hosts
    • Asexual reproduction occurs in intermediate host forming tissue cysts
  • Host range of sexual stage is unknown for N.caninum
    • Intermediate host for N.hughesi is the horse, but the definitive host is unknown
  • Final host
    • Dogs pass oocysts
    • Role not fully understood in pathogenesis
    • 5 day prepatent period
    • Other wild canids may also act as final definitive hosts
  • Intermediate host
    • Mostly cattle
    • Natural infection has been documented in other herbivores
  • Transmission
    • Transplacental infection occurs in all intermediate hosts and in the canine final host
      • Transplacental transmission can occur in successive pregnancies
    • In cattle, vertical transmission occurs
      • Post-natal infection occurs but is less common


Pathogenesis

Dog Neosporosis

Cattle Neosporosis

Horse Neosporosis