Difference between revisions of "Campylobacter jejuni"

Revision as of 21:32, 10 May 2010

Campylobacter jejuni

Widespread on farms - hyperendemic
Carried as commensals in intestines of cattle, sheep, dogs, wild birds and especially chickens
Farm animals regularly exposed via faecal-oral route; maternal antibody protects while active immunity develops
Animals with little exposure are very susceptible, e.g. humans, pets
Most chicken carcasses contaminated, leading to food poisoning and enterocolitis in people from uncooked meat
Colonisation, attachment and invasion of colonic enterocytes; toxin production
Necrosis of colonic absorptive epithelial cells, erosion of mucosa, crypt abscesses, inflammatory infiltrate of neutrophils into mucosa causes colitis
Enteritis and diarrhoea in susceptible dogs; treatment with enrofloxacin
Causes abortion in ewes
Usually asymptomatic infections in chickens and turkeys, but occasional outbreaks of avian hepatitis occur with decreased egg production, loss of condition, haemorrhage and necrosis of liver; phase contrast microscopy demonstrates curved rods in bile; in-feed dihydrostreptomycin sulphate in outbreak
Implicated in undifferentiated neonatal calf diarrhoea, a mixed viral enteritis in calves

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-{{OpenPagesTop}}
+===[[Intestine Pathogens - Pathology#Campylobacter jejuni|''Campylobacter jejuni'']]===
-Also known as: '''''C. jejuni — C. fetus subsp jejuni — Vibrio jejuni'''''
-{{Taxobox
-|name               =''Campylobacter jejuni''
-|phylum             =Proteobacteria
-|class              =Epsilon Proteobacteria
-|order              =Campylobacterales
-|family             =Campylobacteraceae
-|genus              =[[:Campylobacter species|Campylobacter]]
-|species            =''C.jejuni''
-}}
-==Introduction==
-[[File:jejuni.jpg|thumb|200px|right|''Campylobacter jejuni'' Marco Tolo 2006, WikiMedia Commons]]
-''Campylobacter jejuni'' belongs to the genus [[Campylobacter species - Overview|''Campylobacter'']]. ''C.jejuni'' is an '''important enteropathogen of man and a number of animal species'''. Although ''C. jejuni'' rarely causes fatal disease in animals, it is the leading cause of foodborne diseases in humans. It is the '''largest cause of food-poisoning in the UK''' and is therefore a public health issue causing diarrhoea and cramps.
-It also causes late abortion and still births in sheep and goats, and may also cause [[:Category:Mastitis|mastitis]] in cattle. It is widespread on farms and is hyperendemic. It can be carried as commensals in the intestines of cattle, sheep, goats, dogs, cats, rabbits, wild birds and especially chickens.  Farm animals are regularly exposed via the faecal-oral route. Maternal antibody protects the animal while the active immunity develops.
+*Widespread on farms - hyperendemic
+*Carried as commensals in intestines of cattle, sheep, dogs, wild birds and especially chickens
-Animals with little exposure are very susceptible, e.g. humans and pets. Humans can become infected by faecal contaminated poultry skin, meat, milk and water sources. It can also be spread by humans via poor hygiene and during food processing. Most chicken carcasses are contaminated, leading to food poisoning and enterocolitis in people from uncooked meat. If frozen chicken is inadequately thawed, bacteria may remain viable in the abdominal cavity.
+*Farm animals regularly exposed via faecal-oral route; maternal antibody protects while active immunity develops
+*Animals with little exposure are very susceptible, e.g. humans, pets
-''C. jejuni'' causes enteritis and diarrhoea in susceptible dogs and causes abortion in ewes. It usually causes asymptomatic infections in chickens and turkeys, but occasional outbreaks of avian [[ Hepatitis, Acute|hepatitis]] occur. It is implicated in [[Calf Diarrhoea, Undifferentiated
+*Most chicken carcasses contaminated, leading to food poisoning and enterocolitis in people from uncooked meat
-Neonatal|undifferentiated neonatal calf diarrhoea]], a mixed viral enteritis in calves.
+*Colonisation, attachment and invasion of colonic enterocytes; toxin production
+*Necrosis of colonic absorptive epithelial cells, erosion of mucosa, crypt abscesses, inflammatory infiltrate of [[Neutrophils - WikiBlood|neutrophils]] into mucosa causes colitis
-==Pathogenesis==
+*Enteritis and diarrhoea in susceptible dogs; treatment with enrofloxacin
-The pathogenesis of ''C.jejuni'' involves the colonisation, attachment and invasion of colonic enterocytes and toxin production.
+*Causes abortion in ewes
+*Usually asymptomatic infections in chickens and turkeys, but occasional outbreaks of avian hepatitis occur with decreased egg production, loss of condition, haemorrhage and necrosis of liver; phase contrast microscopy demonstrates curved rods in bile; in-feed dihydrostreptomycin sulphate in outbreak
-It causes colitis, characterised by:
+*Implicated in [[Intestines Catarrhal Enteritis - Pathology#Undifferentiated Neonatal Calf Diarrhoea|undifferentiated neonatal calf diarrhoea]], a mixed viral enteritis in calves[[Category:Campylobacter_species]][[Category:Dog]][[Category:Cattle]][[Category:Sheep]]
-:Necrosis of absorptive epithelial cells
-:Erosion of the mucosa
-:Crypt abscesses
-:Infiltration of inflammatory cells into the mucosa and the presence of primarily [[Neutrophils|neutrophils]].
-The bacteria's functional flagella are important as virulence factors. Non-flagellate [[Campylobacter species - Overview|''Campylobacter'']] do not colonise in vivo, and are less invasive.
-{{Learning
-|literature search = [http://www.cabdirect.org/search.html?q=%28%28title%3A%28%22Campylobacter+jejuni%22%29+AND+yr%3A%5B2000+TO+2010%5D%29%29+AND+%28%28title%3A%28%22Campylobacter+jejuni%22%29+AND+ab%3A%28%22Food+safety%22%29+OR+ab%3A%28%22Public+health%22%29%29%29&fq=subject_facet%3A%22Campylobacter+jejuni%22&fq=gl_facet%3A%22UK%22 ''Campylobacter jejuni'' in the UK]
-|full text = [http://www.cabi.org/cabdirect/FullTextPDF/2009/20093305608.pdf '''Campylobacter jejuni - a monographic study (review).''' Corcionivoschi, N.; Drinceanu, D.; Ştef, L.; Julean, C.; Universitatea de Ştiinţe Agricole şi Medicină Veterinară a Banatului Timişoara, Timişoara, Romania, Lucrări Ştiinţifice - Zootehnie şi Biotehnologii, Universitatea de Ştiinţe Agricole şi Medicină Veterinară a Banatului Timişoara, 2009, 42, 1, pp 26-34, 48 ref. - '''Full Text Article''']
-}}
-{{review}}
-{{OpenPages}}
-[[Category:Zoonoses]]
-[[Category:Campylobacter_species]]
-[[Category:Enteritis,_Bacterial]]
-[[Category:Expert Review - Bacteria]]

Difference between revisions of "Campylobacter jejuni"

Revision as of 21:32, 10 May 2010

Campylobacter jejuni

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