Difference between revisions of "Category:Parasites"

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==Immunity to parasites==
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<big>'''[[Immunity to Parasites]]'''</big>
The first line of defence against parasitic infection are the effector mechanisms of the innate immune system:
 
*'''Macrophages'''- important in the defence against extracellular parasites, macrophages are able to secrete cytokines as well as perform phagocytosis
 
**Can act as 'killer cells' through antibody-dependent cell-mediated cytotoxicity, e.g. specific IgG/IgE enhances the ability of macrophages to kill schistosomules
 
**The secretion of TNF-alpha:
 
***Activates other macrophages
 
***Renders hepatocytes resistant to malarial infection when in conjunction with IL-1
 
***Can have toxic effects in high amounts
 
**When activated by cytokines, killing mechanisms using free radicals and O2-independent toxins (e.g. nitric oxide) are enhanced
 
*'''[[Neutrophils - WikiBlood|Neutrophils]]'''- similar properties to macrophages
 
**Activated by cytokines such as TNF-alpha, IFN-γ and GM-CSF, [[[[Neutrophils - WikiBlood|Neutrophils]] - WikiBlood|neutrophils]] produce a more intense respiratory burst and extracellular killing is mediated by H2O2
 
**Present in parasite-infected inflammatory lesions
 
**Express Fc and complement receptors- can participate in antibody-dependent cell-mediated cytotoxicity
 
*'''Eosinophils'''- less phagocytic than [[[[Neutrophils - WikiBlood|Neutrophils]] - WikiBlood|neutrophils]], but important in the destruction of larger parasites
 
**Most activity is controlled by antigen-specific mechanisms, e.g. binding to worms coated with IgG/IgE increases degranulation
 
**The killing of some larvae is enhanced by the activity of mast cells, e.g. antigens released by S. mansoni cause IgE-dependent degranulation of mast cells, the products of which selectively attract eosinophils
 
*'''Platelets'''- cytotoxic activity is increased by cytokines such as TNF-alpha and IFN-γ
 
**Potential targets include the larval stage of flukes, e.g. ''T. gondii'' and ''T. cruzi''
 
**Like other effector cells, platelets express Fc receptors, making them able to perform antibody-dependent cytotoxicity
 
 
 
Although the innate immune system provides an effective first line of defence, T cells are fundamental in the development of immunity, demonstrated using T-cell deprived mice that fail to resolve otherwise non-lethal infections of, for example, ''T. cruzi''.
 
*Both CD4+ and CD8+ cells are required for protection, e.g CD4+ cells protect against the blood stage of a Plasmodium infection (erythrocytes do not express MHC class I), while CD8+ cells are required to mediate immunity against the liver stage (hepatocytes do not express MHC class II).
 
*Th1 cells are required to fight intracellular protozoa- the release of IFN-γ activates macrophages to kill the protozoa residing within them
 
*Helminth infections require both Th1 and Th2 responses, e.g. during ''S. mansoni'' the secretion of IFN-γ by Th1 cells activates mechanisms that destroy larvae in the lungs, although the Th2 subset, secreting IL-5, predominate
 
*Th2 cells are required for the destruction of intestinal worms, where they induce mucosal mast cells and interact with eosinophils
 
While cell-mediated immunity is important in tissue infections, such as Leishmania, specific antibodies are important in controlling parasites that live in the bloodstream, e.g. malaria. Mechanisms of antibody-mediated immunity include:
 
*Directly damaging protozoa
 
*Activating complement
 
*Blocking attachment to host cells
 
*Enhancing macrophage phagocytosis
 
*Involvement in antibody-dependent cell-mediated cytotoxicity
 
 
 
'''Immunopathology'''
 
*The increase in macrophages and lymphocytes in the liver and spleen can lead to swelling of these organs, e.g. visceral leishmaniasis
 
*T-cell dependent granulomas forming in organs, e.g. schistosomiasis in the liver
 
*The pathology of elephantiasis is thought to be due to changes in the adult filariae in the lymphatic system
 
*Formation of immune complexes, e.g. deposition in the kidney during malarial infection
 
*Anaphylactic shock caused by IgE production, e.g. after the rupture of hydatid cysts
 
*Cross-reaction of antibodies with host tissue, e.g. ''O. volvulus'', the cause of river blindness, expresses an antigen similar to a protein in the retina
 
*Excessive production of cytokines, such as TNF-alpha, may contribute to pathology of diseases such as malaria
 
 
 
'''Evading immune defences''':
 
*Selection of innapropriate defences- by exploiting the 'adjuvant' mechanism, some parasites are able to activate the inappropriate helper T cell subset, e.g Leishmania
 
*Antigenic variation avoids recognition by antibody and complement, e.g. ''T. brucei''
 
*Inhibiting fusion of lysosomes
 
*Escaping into the cytoplasm, e.g. ''T. cruzi''
 
*Inhibiting respiratory burst, e.g. Leishmania
 
*Forming cysts in muscle tissue, e.g. ''T. spiralis''- also develops decay accelerating factor (DAF)
 
*Production of antioxidants, e.g. ''W. bancrofti''
 
 
 
  
  

Revision as of 19:51, 17 May 2010

Introduction

Parasitology is the relationship between two organisms where one is living at the expense of the other. Parasites are highly specialised, have nutritional dependence on the host and can avoid an immunological attack. They have evolved to integrate their life cycle with that of their host species.

The two main groups of parasites are the microparasites and the macroparasites. Protozoa are microparasites as they multiply within the host. Macroparasites on the other hand, establish themselves in or on the host but produce eggs or larvae which are dispersed to the environment. Macroparasites include helminths and arthropods. The number of macroparasites in the body reflects the number which invaded the animal.

Parasites can evade an immune response from the host by changing the antigens presented to the host, produce antigens that mimic the host's antigens and can produce down-regulating factors which suppress or modify the host's immune responses. Having a rapid turnover of their surface coat when host cells bind and by being able to live in sites which are protected from the host's immune response allow parasites to establish themselves in a particular species.


Immunity to Parasites


Parasitology

Division by Class:


Antiparasitic Drugs

Parasite Flashcards

Useful Resources

Sea Lice - Copyright Joseph G. Kunkel at The Kunkel Fish & Aquatic Invert Site
Mites parasitising a harvestman - Wikimedia Commons

Information on the diagnostic tests, collecting of samples and identification of parasites

WikiWords

A glossary of the important concepts and terms in parasitology

References

This section relies heavily on lecture notes and input from:

  • Professor Dennis Jacobs
  • Dr Mark T Fox BVetMed PhD HFEA DipEVPC MRCVS

Other sources

  • Wall and Shearer: Veterinary Entomology
  • Taylor, Coop and Wall: Veterinary Parasitology, third edition

Subcategories

This category has the following 3 subcategories, out of 3 total.

A

H

P

Pages in category "Parasites"

The following 3 pages are in this category, out of 3 total.