Difference between revisions of "Canine Adenovirus 1"

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(Created page with 'Causes Infectious canine tracheitis ====Hosts==== *Dogs *Foxes are very susceptible (Fox Encephalitis) ====Pathogenesis==== *Infects and replicates in the oropharynx *Viremia a…')
 
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Causes Infectious canine tracheitis
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Causes Infectious canine hepatitis
 
 
 
====Hosts====
 
====Hosts====
 
*Dogs
 
*Dogs

Revision as of 20:14, 17 May 2010

Causes Infectious canine hepatitis

Hosts

  • Dogs
  • Foxes are very susceptible (Fox Encephalitis)

Pathogenesis

  • Infects and replicates in the oropharynx
  • Viremia as the virus reaches endothelial cells
  • Attacks the endothelial lining of gall bladder, liver sinusoids, and Kuppfer cells
  • Resulting heptatitis is followed by severe abdominal pain and often death
  • Post Mortem: swollen, hemorrhagic liver, ascites, and oedema of the gall bladder
  • In older dogs, may present more mildly with lymph node enlargement and chronic interstitial nephritis
  • In foxes: virus replicates in the endothelia of the brain resulting in neuronal damage, fits, and paralysis

Epidemiology

  • Transfers easily via ingesting infected urine, feces or respiratory secretions
  • Can be transferred by handlers, infected surfaces, etc.

Diagnosis

  • Intranuclear inclusion bodies in hepatocytes can be seen under H&E staining
  • Vascular endothelium can be stained for viral antigen by immunofluorescence

Control

In an outbreak

  • Isolate infected dogs
  • Disinfect premises

To prevent

  • Vaccination: tissue culture adaptation that may be live or inactivated
  • Cross protection with CAV2
  • Live vaccines are known to cause keratitis in Afghans, Red Setters and Saluki