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| | <categorytree mode=pages>Rhabdoviridae</categorytree> | | <categorytree mode=pages>Rhabdoviridae</categorytree> |
| − | |logo =Vesicular stomatitis virus logo.jpg | + | |logo =Vesicular stomatitis virus logo.png |
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| | ##Fish Rhabdoviruses, such as viral hemorrhagic syndrome and infectious haematopoetic necrosis virus | | ##Fish Rhabdoviruses, such as viral hemorrhagic syndrome and infectious haematopoetic necrosis virus |
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| − | ==Virulence and Pathogenesis==
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| − | *Rabies is moderately resistant: it can survive well in dark places at low temperatures for several days
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| − | *Infection occurs through a '''penetrating bite''' in which virus is transmitted via '''saliva'''
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| − | *'''Incubation''' period is variable but can be long (10 days to 12 months), and increases with distance of the bite to the CNS
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| − | **80% show signs within 4 months
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| − | *Primary replication of the virus occurs in the '''muscle'''
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| − | *The virus gains access to nervous tissue and travels toward the '''brain''', where it continues to replicate
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| − | *It then migrates down cranial nerves to infect salivary glands and the cornea
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| − | *Virus is shed in '''saliva''' and '''tears''' and can be shed BEFORE the onset of classical signs
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| − | *The onset of clinical signs in dogs and cats includes:
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| − | **Behavioral changes
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| − | **Pyrexia
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| − | **Salivation
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| − | **Dilation of pupils
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| − | *Two forms of the virus exist:
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| − | **'''Furious''' form:
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| − | ***Common to cats and dogs
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| − | ***Abnormal aggression, salivation, and attack without provocation
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| − | ***Disordered wandering, "copulatory" movements.
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| − | ***Incoordination, convulsions, coma and death within 3-10 days
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| − | **'''Dumb''' form
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| − | ***May or may not follow Furious form
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| − | ***Common to ruminants and horses
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| − | ***Ruminal tympany, tenesmus, diarrhoea
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| − | ***Paralysis of lower jaw, drooling saliva, tremors and progressive paralysis
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| − | ***In dogs, a change in voice may be observed (bellowing)
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| − | *Human infection is characterized by '''hydrophobia'''
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| | [[Category:Viruses]] | | [[Category:Viruses]] |