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Cholestasis, Molecular Pathogenesis (view source)
Revision as of 22:15, 6 June 2010
, 22:15, 6 June 2010no edit summary
*Calcium signaling within and between hepatocytes decreases with choleostasis – changes in gap junctions so may change microperistalsis down the terminal canaliculi to the bile ducts in the portal triads (counter to direction of blood flow).
*Calcium signaling within and between hepatocytes decreases with choleostasis – changes in gap junctions so may change microperistalsis down the terminal canaliculi to the bile ducts in the portal triads (counter to direction of blood flow).
*cAMP mediated signaling in the hepatocyte is impaired due changes in G protein expression and localization. This together with changes in membrane composition and the detergent effects of the bile salts – contribute to decreased adenylate cyclase activity. Also therefore decrease effects of glucagons and VIP that normal stimulate bile secretion.
*cAMP mediated signaling in the hepatocyte is impaired due changes in G protein expression and localization. This together with changes in membrane composition and the detergent effects of the bile salts – contribute to decreased adenylate cyclase activity. Also therefore decrease effects of glucagons and VIP that normal stimulate bile secretion.
[[Category:Liver_-_General_Pathology]]