Difference between revisions of "Liver, Hydropic Degeneration"

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(Created page with '*a general histopathological finding in which cells absorb much water, indicating ischaemic or toxic injury or early autolysis *common and non-specific ===causes=== 1. anoxia 2…')
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[[Category:Liver - Degenerative Pathology]]
 
[[Category:Liver - Degenerative Pathology]]
[[Category:To_Do_-_Clinical]]
 

Revision as of 12:49, 7 June 2010

  • a general histopathological finding in which cells absorb much water, indicating ischaemic or toxic injury or early autolysis
  • common and non-specific

causes

1. anoxia

2. mild toxins

3. sustained bile stasis

4. excess glucocorticoids in the body

  • glucose is normally stored within hepatocytes as glycogen
  • excess glycogen within hepatocytes causes mild swelling and gives a focal hydropic appearance in areas of the liver
  • usually no change grossly - possible lightening of colour if pronounced and widespread

endogenous causes

  • Hyperadrenocortism (Cushing's syndrome)
    • functional pituitary or adrenocortical tumours
  • Diabetes mellitus [link to DM page]

exogenous causes

  • iatrogenic
    • most common cause in the dog
    • due to prolonged use of steroid therapy eg skin disease