Difference between revisions of "Endocrine Pancreas - Pathology"

From WikiVet English
Jump to navigation Jump to search
Line 15: Line 15:
 
===[[Carcinoma]]s===
 
===[[Carcinoma]]s===
  
===Gastrinoma===
+
===[[Gastrinoma]]===
[http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=7762 Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine]
 
*Described in dogs, cats
 
*Known as Zollinger-Ellison syndrome in humans
 
*Uncommon compared to beta cell neoplasms
 
*Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and [[Duodenum - Anatomy & Physiology|duodenal]] ulceration
 
====Clinical signs====
 
*Anorexia
 
*Severe weight loss
 
*[[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]]
 
*[[Diarrhoea]]
 
*Dehydration
 
====Pathology====
 
*Multiple variably sized neoplasms
 
*Increased connective tissue mass - firm
 
*Partiallty encapsulated
 
*Invade locally
 
*Metastases to [[Liver - Anatomy & Physiology|liver]] and local lymph nodes are common
 
  
 
===Glucagonoma===
 
===Glucagonoma===

Revision as of 13:40, 9 June 2010



Pancreas, Endocrine - Degenerative Pathology

Neoplasia

Insulin Secreting Neoplasms

Insulinoma

Carcinomas

Gastrinoma

Glucagonoma

  • Very rare
  • Characterised by
    • Hyperglycaemia
    • Vacuolar hepatopathy
    • Skin erythema with superficial necrotising dermatitis
  • Diagnosis in dogs is difficult as presents together with DM