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Category:Cardiovascular System - Developmental Pathology (view source)

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*Environmental; Includes infection (usually viral), chemical, nutritional and physical factors.

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Understanding the normal development of the heart and great vessels allows an understanding of the morphology and pathology of the congenital abnormalities seen in mammals.

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Understanding the [[Developmental Anatomy of the Heart - Anatomy & Physiology|normal development of the heart and great vessels]] allows an understanding of the morphology and pathology of the congenital abnormalities seen in mammals.

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~~==Normal Development==~~

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~~The heart develops from a simple endothelial tube which acquires a mesodermal layer (forms myocardium and epicardium).~~

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As the heart grows a flexure forms so that the original cranial portion becomes the truncus arteriosus and the ventricles and the oringinal caudal part of the tube will form the sinus venosus and the atria.

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~~The atria are separated by a growth from the dorsal wall, the septum primum and ventral wall, the septum secundum.~~

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~~The ventricles are separated by a septum growing from the apex.~~

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~~Congenital abnormalities can be broadly classified into 3 groups:~~

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*Abnormalities of chamber development forming '''shunts'''.

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*Abnormalities of great vessels forming '''shunts''' or '''anomalies'''.

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*Abnormalities of valve formation resulting in '''dysplasias'''.

==Chamber Development==

Bara

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