Difference between revisions of "Sendai Virus"

Revision as of 12:37, 12 June 2010

Murine Parainfluenza - 1 (Sendai Virus)

Endemic in many mouse colonies
Most mice show no symptoms due to maternal antibodies
But minor respiratory lesions may invalidate carcinogenic or toxicological studies
Immunological studies also confused due to virus activating NK cells via high circulating IF 3-4 days post-infection
Control achieved by:
- Purchasing specific pathogen free (SPF) mice
- Kill whole colony in an outbreak -> disinfection -> formalin fumigation

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-{{OpenPagesTop}}
+===Murine Parainfluenza - 1 ([[Sendai Virus]])===
-Also known as: '''''Murine Parainfluenza - 1'''''
+*Endemic in many '''mouse''' colonies
+*Most mice show no symptoms due to maternal antibodies
-== Introduction ==
+*But minor respiratory lesions may invalidate carcinogenic or toxicological studies
+*Immunological studies also confused due to virus activating [[Lymphocytes#Natural Killer (NK) Cells|NK cells]] via high circulating [[Innate Immune System - WikiBlood#Interferons|IF]] 3-4 days post-infection
-Sendai virus is of the family [[Paramyxovirinae|Paramyxoviridae]]. It is endemic in '''mouse''' colonies worldwide, but rarely shows as a clinical disease as maternal antibody is usually high so the disease rarely has any clinical effects.
+*Control achieved by:
+**Purchasing '''specific pathogen free (SPF)''' mice
-== Clinical Signs ==
+**Kill whole colony in an outbreak -> disinfection -> formalin fumigation
+[[Category:Paramyxovirinae]][[Category:Rodents]]
-There may be mild clinical signs related to the respiratory tract such as nasal discharge or coughing and increased respiratory rate. The animal may be inappetant and lethargic for a short period.
-== Diagnosis ==
-Virus isolation is diagnostic.
-== Control ==
-Control is achieved by purchasing '''specific pathogen free (SPF)''' mice, which have been screened serologically as having not been exposed to many viruses and bacteria. This is obviously only available in large scale laboratories.
-In the cases of an outbreak, the whole colony should be destroyed and disinfection and formalin fumigation should take place.
-== References ==
-Blood, D.C. and Studdert, V. P. (1999) '''Saunders Comprehensive Veterinary Dictionary '''(2nd Edition),'' Elsevier Science ''
-Bridger, J and Russell, P (2007) '''Virology Study Guide,''''' Royal Veterinary College ''
-Paterson, S (2006) '''Skin Diseases of Exotic Pets,''''' Blackwell Publishing ''
-Roberts, W.A. and Carter, G.A.(1976) '''Essentials of Veterinary Virology,''''' Michigan State University Press, East Lansing, Michigan ''
-{{review}}
-{{OpenPages}}
-[[Category:Paramyxovirinae]] [[Category:Rodents]] [[Category:Expert_Review]]

Difference between revisions of "Sendai Virus"

Revision as of 12:37, 12 June 2010

Murine Parainfluenza - 1 (Sendai Virus)

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