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Text replace - 'Overview of Haematopoiesis - WikiBlood' to 'Haematopoiesis'
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<p>Leukopoiesis is the process of formation of [[Leukocytes|leukocytes]] (white blood cells) from stem cells in haematopoietic organs. Leukocytes develop from either multipotential myeloid stem cells ([[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]]) or multipotential lymphoid stem cells ([[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-L]]). </p>
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<p>Leukopoiesis is the process of formation of [[Leukocytes|leukocytes]] (white blood cells) from stem cells in haematopoietic organs. Leukocytes develop from either multipotential myeloid stem cells ([[Haematopoiesis#Colony Forming Units|CFU-GEMM]]) or multipotential lymphoid stem cells ([[Haematopoiesis#Colony Forming Units|CFU-L]]). </p>
<p>[[Leukocytes|Leukocytes]] developing from CFU-GEMM’s are granulocytes ([[Neutrophils|neutrophils]], [[Basophils| basophils]] and [[Eosinophils| eosinophils]]) or [[Monocytes|monocytes]] and [[Leukocytes|leukocytes]] developing from [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-L]]'s are lymphocytes (T & B cells, dendritic and NK cells).</p>
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<p>[[Leukocytes|Leukocytes]] developing from CFU-GEMM’s are granulocytes ([[Neutrophils|neutrophils]], [[Basophils| basophils]] and [[Eosinophils| eosinophils]]) or [[Monocytes|monocytes]] and [[Leukocytes|leukocytes]] developing from [[Haematopoiesis#Colony Forming Units|CFU-L]]'s are lymphocytes (T & B cells, dendritic and NK cells).</p>
 
[[Image:Leukopoiesis pathway.jpg|right|thumb|400px|'''Leukopoiesis pathway''']]
 
[[Image:Leukopoiesis pathway.jpg|right|thumb|400px|'''Leukopoiesis pathway''']]
    
==Granulopoiesis==
 
==Granulopoiesis==
All granulocytes develop from the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]] cells.
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All granulocytes develop from the [[Haematopoiesis#Colony Forming Units|CFU-GEMM]] cells.
 
===Summary of pathways===
 
===Summary of pathways===
 
<div style="text-align: center;">
 
<div style="text-align: center;">
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===[[Neutrophils|Neutrophils]]===
 
===[[Neutrophils|Neutrophils]]===
Under the stimulation of GM-CSF, G-CSF and Il-3 the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]] differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GM]], the common precursor for both neutrophils and monocytes. This then further differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-G]].
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Under the stimulation of GM-CSF, G-CSF and Il-3 the [[Haematopoiesis#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-GM]], the common precursor for both neutrophils and monocytes. This then further differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-G]].
 
====Stages====
 
====Stages====
 
=====Myeloblast=====
 
=====Myeloblast=====
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<br>
 
<br>
 
===[[Basophils|Basophils]]===
 
===[[Basophils|Basophils]]===
Under the stimulation of GM-CSF and Il-3 the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]] differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Ba]].
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Under the stimulation of GM-CSF and Il-3 the [[Haematopoiesis#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-Ba]].
 
====Stages====
 
====Stages====
 
===== Myeloblast & Promyelocyte=====
 
===== Myeloblast & Promyelocyte=====
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===[[Eosinophils|Eosinophils]]===
 
===[[Eosinophils|Eosinophils]]===
Under the stimulation of GM-CSF, Il-3 and Il-5 the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]] differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Eo]].
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Under the stimulation of GM-CSF, Il-3 and Il-5 the [[Haematopoiesis#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-Eo]].
 
====Stages====
 
====Stages====
 
===== Myeloblast & Promyelocyte=====
 
===== Myeloblast & Promyelocyte=====
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==Monocyte development==
 
==Monocyte development==
[[Monocytes|Monocytes]] develop from the same precursor as [[Neutrophils|neutrophils]] the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.
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[[Monocytes|Monocytes]] develop from the same precursor as [[Neutrophils|neutrophils]] the [[Haematopoiesis#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.
 
===Stages===
 
===Stages===
 
====Monoblast====
 
====Monoblast====
First stage after cell has differentiated into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-M]].
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First stage after cell has differentiated into the [[Haematopoiesis#Colony Forming Units|CFU-M]].
 
====Promonocyte====
 
====Promonocyte====
 
Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing (acting as a reservoir).
 
Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing (acting as a reservoir).
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==Lymphopoiesis==
 
==Lymphopoiesis==
<p>[[Lymphocytes|Lymphocytes]] develop from the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-L]]'s. Those destined to become [[Lymphocytes#T cells|T cells]] leave the [[Bone Marrow - Anatomy & Physiology|bone marrow]] and migrate to the [[Thymus - Anatomy & Physiology|thymus]], and those destined to be [[Lymphocytes#B cells|B cells]] migrate to the [[Spleen - Anatomy & Physiology|spleen]] and GALT or proliferate directly from the [[Bone Marrow - Anatomy & Physiology|bone marrow]].</p><p>Follow these links for a more detailed explanation on [[T cell differentiation - WikiBlood|T cell development]] and [[B cell differentiation - WikiBlood |B cell development]].</p>
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<p>[[Lymphocytes|Lymphocytes]] develop from the [[Haematopoiesis#Colony Forming Units|CFU-L]]'s. Those destined to become [[Lymphocytes#T cells|T cells]] leave the [[Bone Marrow - Anatomy & Physiology|bone marrow]] and migrate to the [[Thymus - Anatomy & Physiology|thymus]], and those destined to be [[Lymphocytes#B cells|B cells]] migrate to the [[Spleen - Anatomy & Physiology|spleen]] and GALT or proliferate directly from the [[Bone Marrow - Anatomy & Physiology|bone marrow]].</p><p>Follow these links for a more detailed explanation on [[T cell differentiation - WikiBlood|T cell development]] and [[B cell differentiation - WikiBlood |B cell development]].</p>
 
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