Difference between revisions of "Burkholderia pseudomallei"
Jump to navigation
Jump to search
(Redirected page to Melioidosis) |
|||
(10 intermediate revisions by 2 users not shown) | |||
Line 1: | Line 1: | ||
− | + | *Causes [[Respiratory Bacterial Infections - Pathology#Melioidosis (Pseudoglanders)|melioidosis]] - endemic in Asia and Australia | |
− | + | *Primarily infects rodents | |
− | [[Category:Pseudomonas_and_Burkholderia_species | + | *Pathogenesis: |
+ | **Infection via ingestion, inhalation or skin wounds from environment | ||
+ | **Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity | ||
+ | **Strain virulence and host immunosuppression important | ||
+ | *Clinical infections: | ||
+ | **Opportunistic infection with stress and immunosuppression predisposing to disease | ||
+ | **Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract | ||
+ | **Chronic, debilitating, progressive disease with long incubation period | ||
+ | **Many animal species susceptible | ||
+ | **Referred to as pseudoglanders in horses | ||
+ | *Diagnosis: | ||
+ | **Specimens: pus from abscesses, affected tissues, blood | ||
+ | **Fluorescent antibody technique on tissue smears | ||
+ | **Blood agar and MacConkey agar plates, incubated aerobically | ||
+ | **Colonies have musty smell | ||
+ | **Lactose fermentation on MacConkey | ||
+ | **Slide agglutination | ||
+ | **ELISA, complement fixation and indirect haemagglutination tests for serum antibodies | ||
+ | *Treatment/control: slaughter of infected animals where exotic[[Category:Pseudomonas_and_Burkholderia_species]][[Category:Rodents]] | ||
+ | [[Category:To_Do_-_Bacteria]] |
Revision as of 10:56, 25 June 2010
- Causes melioidosis - endemic in Asia and Australia
- Primarily infects rodents
- Pathogenesis:
- Infection via ingestion, inhalation or skin wounds from environment
- Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity
- Strain virulence and host immunosuppression important
- Clinical infections:
- Opportunistic infection with stress and immunosuppression predisposing to disease
- Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract
- Chronic, debilitating, progressive disease with long incubation period
- Many animal species susceptible
- Referred to as pseudoglanders in horses
- Diagnosis:
- Specimens: pus from abscesses, affected tissues, blood
- Fluorescent antibody technique on tissue smears
- Blood agar and MacConkey agar plates, incubated aerobically
- Colonies have musty smell
- Lactose fermentation on MacConkey
- Slide agglutination
- ELISA, complement fixation and indirect haemagglutination tests for serum antibodies
- Treatment/control: slaughter of infected animals where exotic