Difference between revisions of "Bacillary Haemoglobinuria"

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Also known as: '''''Red Water'''
+
====Bacillary Haemoglobinuria (Red Water)====
 +
*''[[Clostridium haemolyticum]]'' AKA ''Clostridium novyi'' Type D
 +
*cattle and sheep
 +
*highly fatal
 +
*similar pathogenesis to ''C. novyi''
 +
*beta toxin produced
 +
**causes hepatic necrosis and intravascular haemolysis
 +
*C. haemolyticum found in soil, poorly drained/wet pastures
 +
*spores found routinely in [[Liver - Anatomy & Physiology|liver]] and GIT and faeces of grazing animals in affected pastures
 +
*need disease in [[Liver - Anatomy & Physiology|liver]] casing anaerobic conditions to allow bacterial growth and toxin production
 +
*normally associated with [[Liver - Anatomy & Physiology|Liver]] Fluke damage
 +
*disease occurs in some areas and some farms - distribution is poorly understood
 +
=====Clinical Signs=====
 +
*found dead/sudden death
 +
**lateral recumbency
 +
**bloat
 +
**little signs of struggle
 +
**blood in nostrils, mouth, [[Rectum - Anatomy & Physiology|rectum]], [[Female Reprodcutive Tract -The Vagina/Vestibule - Anatomy & Physiology|vagina]]
 +
*IF seen alive
 +
**depressed, reluctant to move, pyrexia, respiratory distress
 +
**red urine (haemoglobinuria) but not consistent
 +
**pale mucous membranes/jaundice
 +
**bloody froth in nostrils
  
−
Caused by: '''''Clostridium haemolyticum''''' (also known as ''Clostridium novyi'' type D)
+
=====Gross=====
 +
*post mortem is confirmatory finding
 +
*rapid decomposition of carcass
 +
**organs decomposed
 +
*subcutaneous hameorrhages, odema, emphysema
 +
*blood stained abdominal and thoracic fluid, large quantity and pericardium
 +
*animal is severely anaemic
 +
*may be jaundiced
 +
*red urine in [[Urinary Bladder - Anatomy & Physiology|bladder]], therefore haemoglobin in urine
 +
*[[Urinary System - Anatomy & Physiology#Upper Urinary System|kidneys]] speckled with haemoglobin
 +
*blood in lungs/trachea
 +
*ischaemic hepatic infarct
 +
**usually a single large necrotic focus in the [[Liver - Anatomy & Physiology|liver]]
 +
**area of necrosis, sometimes partially liquefied centre, irregular outline with a hyperaemic edge
  
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==Introduction==
+
=====Microscopically=====
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A disease of cattle and sheep caused by ''Clostridium haemolyticum'' (also known as ''Clostridium novyi'' type D) a bacteria from the class [[:Category:Clostridium species|''Clostridia'']]. ''C. haemolyticum'' is found in soil, poorly drained/wet pastures and is highly fatal to livestock. The bacteria produces a beta toxin which causes hepatic necrosis and intravascular haemolysis. Destruction of [[Erythrocytes|red blood cells]] results in haemoglobinuria.
+
*presence of Clostridia post mortem must be interpreted with great caution as they are common post mortem invaders
 +
*FAT for organism
 +
*identification of toxins
 +
**need this for diagnosis
  
−
Often associated with a disease in the [[Liver - Anatomy & Physiology|liver]] that causes anaerobic conditions allowing the growth of bacteria and hence toxin production. Endospores are dormant within the liver and germination is triggered by damage to the tissue. The damage to the liver is frequently caused by [[Fasciola hepatica|liver fluke]].
+
=====Treatment=====
 +
*unlikely
 +
*very high doses of penicillin or oxytetracycline
 +
*blood transfusion
 +
=====Prevention=====
 +
*vaccination lasts up to 6 months
 +
*[[Liver - Anatomy & Physiology|liver]] fluke control
 +
*remove infected carcasses from pasture
 +
NB: Distinguish Red Water from [[Black Disease]]!  The former will have bleeding out of any orifice while the latter does not
  
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==Signalment==
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[[Category:Cattle]][[Category:Sheep]][[Category:Hepatitis,_Bacterial]]
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Cattle are the most commonly affected animal but sheep can also be infected. Animals in better body condition seem to be more susceptible to disease.
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[[Category:To_Do_-_Clinical]]
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==Diagnosis==
 
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Often clinical signs are enough to make a presumptive diagnosis. Additionally urine can be collected and [[Urine Analysis - Pathology|urinalysis]] undertaken. This will help to differentiate the presence of haematuria where frank blood is in the urine from haemolysis where haemaglobinuria is present in the urine.
 
−
 
−
A definitive diagnosis can be made by isolating ''C.haemolyticum'' from the liver however it can be difficult to culture. Additionally the organism can be confirmed on fluorescent antibody or immunohistochemical testing of liver tissue.
 
−
 
 
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==Clinical Signs==
 
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Animals can be found dead often in lateral recumbency, [[Bloat|bloat]] and little signs of struggle with blood in the nostrils, mouth, [[Rectum - Anatomy & Physiology|rectum]] and vagina.
 
−
 
 
−
If animals are seen alive, the most obvious sign is a port wine coloured urine that froths on voiding.
 
−
Animals are also often depressed, reluctant to move, pyrexic, have pale mucous membranes and are [[Icterus|jaundiced]] and sometimes in respiratory distress.
 
−
 
 
−
==Pathology==
 
−
Post mortem findings include rapid decomposition of the carcass, organs are also decomposed with subcutaneous haemorrhages, [[Oedema|oedema]] and emphysema present.
 
−
Abdominal and thoracic fluid are blood stained and a large quantity will be in the [[Heart Structure - Anatomy & Physiology#Pericardium |pericardium]].
 
−
The animal is severely anaemic and may be jaundiced.
 
−
Red urine in the [[Urinary Bladder - Anatomy & Physiology|bladder]], and the [[Urinary System Overview - Anatomy & Physiology#Upper Urinary System|kidneys]] will be speckled with haemoglobin.
 
−
There is usually a single large necrotic focus in the liver that is sometimes partially liquefied in the centre, and an irregular outline with a hyperaemic edge.
 
−
 
 
−
Microscopically, fluorescent antibody testing can identify the organism. The presence of ''Clostridia'' post mortem must be interpreted with great caution as they are common post mortem invaders.
 
−
 
 
−
==Treatment==
 
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It is unlikely that cases are recognised early enough for treatment to be effective.
 
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Very high doses of [[Penicillins|penicillin]] or [[Tetracyclines|oxytetracycline]] can be used and animals often need a blood transfusion if possible.
 
−
 
 
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==Prevention==
 
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[[Vaccines|Vaccination]] is available and lasts for up to 6 months. Liver fluke control should also be instituted to prevent any damage to the liver.
 
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Infected carcasses should be removed from pasture as spores can survive for long periods in the soil and carcasses.
 
−
 
 
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==Prognosis==
 
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Often fatal.
 
−
 
 
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==Literature Search==
 
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[[File:CABI logo.jpg|left|90px]]
 
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Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
 
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<br><br><br>
 
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[http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22Bacillary+Haemoglobinuria%22&occuring1=title&rowId=2&options2=OR&q2=%22Red+Water%22&occuring2=title&rowId=3&options3=AND&q3=&occuring3=freetext&x=43&y=12&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Bacillary haemoglobinuria publications]
 
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==References==
 
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Merck & Co (2008) '''The Merck Veterinary Manual''' (Eighth Edition) ''Merial''
 
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{{review}}
 
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[[Category:Liver Diseases - Cattle]][[Category:Liver Diseases - Sheep]][[Category:Hepatitis,_Bacterial]]
 
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[[Category:Lymphoreticular and Haematopoietic Diseases - Cattle]]
 
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[[Category:Brian Aldridge reviewing]]
 

Revision as of 20:51, 28 June 2010

Bacillary Haemoglobinuria (Red Water)

  • Clostridium haemolyticum AKA Clostridium novyi Type D
  • cattle and sheep
  • highly fatal
  • similar pathogenesis to C. novyi
  • beta toxin produced
    • causes hepatic necrosis and intravascular haemolysis
  • C. haemolyticum found in soil, poorly drained/wet pastures
  • spores found routinely in liver and GIT and faeces of grazing animals in affected pastures
  • need disease in liver casing anaerobic conditions to allow bacterial growth and toxin production
  • normally associated with Liver Fluke damage
  • disease occurs in some areas and some farms - distribution is poorly understood
Clinical Signs
  • found dead/sudden death
    • lateral recumbency
    • bloat
    • little signs of struggle
    • blood in nostrils, mouth, rectum, vagina
  • IF seen alive
    • depressed, reluctant to move, pyrexia, respiratory distress
    • red urine (haemoglobinuria) but not consistent
    • pale mucous membranes/jaundice
    • bloody froth in nostrils
Gross
  • post mortem is confirmatory finding
  • rapid decomposition of carcass
    • organs decomposed
  • subcutaneous hameorrhages, odema, emphysema
  • blood stained abdominal and thoracic fluid, large quantity and pericardium
  • animal is severely anaemic
  • may be jaundiced
  • red urine in bladder, therefore haemoglobin in urine
  • kidneys speckled with haemoglobin
  • blood in lungs/trachea
  • ischaemic hepatic infarct
    • usually a single large necrotic focus in the liver
    • area of necrosis, sometimes partially liquefied centre, irregular outline with a hyperaemic edge
Microscopically
  • presence of Clostridia post mortem must be interpreted with great caution as they are common post mortem invaders
  • FAT for organism
  • identification of toxins
    • need this for diagnosis
Treatment
  • unlikely
  • very high doses of penicillin or oxytetracycline
  • blood transfusion
Prevention
  • vaccination lasts up to 6 months
  • liver fluke control
  • remove infected carcasses from pasture

NB: Distinguish Red Water from Black Disease! The former will have bleeding out of any orifice while the latter does not

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