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====Control====
 
====Control====
 
*Cull clinically affected animals
 
*Cull clinically affected animals
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*Also called '''pulmonary carcinomatosis'''
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*Infectious [[Bronchi and Bronchioles Inflammatory - Pathology#Infectious causes of bronchitis or bronchiolitis|bronchiolar]]-[[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|alveolar]] carcinoma caused by a [[Retroviridae|retrovirus]]
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*Commonest under intensive management systems which favour aerosol transmission  and close contact of disease
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*Behaves like chronic pneumonia
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*Takes months to years to express itself clinically as coughing and exercise intolerance
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*Gross pathology:
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**Heavy lungs which fail to collapse
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**The lesions progress from small firm grey/white nodular lesions to extensive confluent areas with replacement by neoplastic tissue
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**Cut surface oozes fluid
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**There is often coexistent infection present
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**Occasional metastases to bronchial and mediastinal lymph nodes can occur
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*Histopathology:
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**Widespread proliferation of alveolar (Type 2) and terminal bronchiolar epithelium, lining the alveoli and lower airways
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**Multiple neoplastic foci of cuboidal/columnar cells forming papillary projections into the lumen
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**Metastases of the same in the bronchial and mediastinal lymph nodes
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*There is no serological test, and diagnosis depends upon raising the animal by the hind limbs whereupon a clear fluid issues from the nose = "Wheelbarrow test"
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*'''[[Jaagsiekte - Pathology|More information]]'''
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[[Category:Mammalian Type D retrovirus ]][[Category:Sheep]]
 
[[Category:Mammalian Type D retrovirus ]][[Category:Sheep]]
 
[[Category:To_Do_-_Viruses]]
 
[[Category:To_Do_-_Viruses]]
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