Difference between revisions of "Black Leg"

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Also known as: '''''Blackquarter
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[[Image:Black leg myositis.jpg|right|thumb|100px|<small><center>Blackleg myositis (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
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{| cellpadding="10" cellspacing="0" border="1"
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| Also known as:
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| '''Blackquarter
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|-
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|}
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==Description==
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A bacterial disease affecting cattle and sheep caused by [[Clostridium chauvoei|''Clostridium chauvoei'']]. Latent spores of this organism are deposited in the muscle and liver of ruminants via the circulation resulting in oedematous and crepitant swelling of the muscles.
  
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==Introduction==
 
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[[Image:Black leg myositis.jpg|right|thumb|300px|<small><center>Blackleg myositis (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
 
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A bacterial disease affecting cattle and sheep caused by [[Clostridium chauvoei|''Clostridium chauvoei'']]. Spores pass through the wall of the GI tract and via the bloodstream enter the muscle and liver where they then lie latent. This results in oedematous and crepitant swelling of the muscles. Under the correct conditions (usually anaerobic following injury) they germinate and bacilli grow. Toxins damage the capillaries causing a severe necrotising myositis.
 
  
 
==Signalment==
 
==Signalment==
 
In cattle it is typically beef breeds who are affected particularly animals in good health and good body condition. More frequently occurs in cattle between 6-24 months old but can affect animals of any age. In some animals lesions occur following muscle trauma, which is thought to activate latent spores in the muscle.
 
In cattle it is typically beef breeds who are affected particularly animals in good health and good body condition. More frequently occurs in cattle between 6-24 months old but can affect animals of any age. In some animals lesions occur following muscle trauma, which is thought to activate latent spores in the muscle.
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In sheep, cases typically occur following some form of injury such as shearing cuts, docking or castration.
 
In sheep, cases typically occur following some form of injury such as shearing cuts, docking or castration.
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Tends to affect animals in the summer months.
 
  
 
==Diagnosis==
 
==Diagnosis==
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Diagnosis is made on clinical signs and muscle biopsy.  
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Diagnosis is made on clinical signs and muscle biopsy. Affected muscle is black, dry and infiltrated with small bubbles. The lesions can be present in any muscle. Often in sheep, lesions are deep and quite small. Suspected cases can be confirmed using demonstration of ''C. chauvoei'' in affected muscle using the fluorescent antibody test.  
  
 
==History and Clinical Signs==
 
==History and Clinical Signs==
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The bacteria can cause rapid toxaemia resulting in sudden death, however, if clinical signs do occur these can include toxaemia, pyrexia, depression, [[Pulmonary Oedema|pulmonary oedema]], circulatory collapse lameness and swollen hot muscles which later become cool as necrosis occurs.
 
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==Pathology==
 
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Affected muscle is black, dry, infiltrated with small bubbles, distended by serous or serosanguinous exudate and often has a rancid smell. The lesions can be present in any muscle including the tongue or diaphragm and it is not unusual to find clumps of gram positive bacteria in affected muscle. Often in sheep, lesions are deep and quite small. Suspected cases can be confirmed using demonstration of ''C. chauvoei'' in diseased muscle using the fluorescent antibody test on smears produced from the primary lesion.
 
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==Treatment==
 
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Vaccination can prevent black leg in cattle and sheep. In the face of an outbreak all susceptible animals should be treated with penicillin and vaccinated.
 
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==Prognosis==
 
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Poor, clinical cases can be treated with penicillin however this is rarely successful.
 
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==Literature Search==
 
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[[File:CABI logo.jpg|left|90px]]
 
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Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
 
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<br><br><br>
 
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[http://www.cabdirect.org/search.html?q=%28%28title%3A%28%22Clostridium+chauvoei%22%29+AND+sc%3A%22ve%22%29%29+OR+%28%28title%3A%28%22blackleg%22%29+OR+title%3A%28%22black+leg%22%29+OR+title%3A%28%22black+quarter%22%29+OR+title%3A%28%22blackquarter%22%29+AND+sc%3A%22ve%22%29%29 Blackleg publications]
 
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==References==
 
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Merck & Co (2008) '''The Merck Veterinary Manual''' (Eighth Edition) Merial
 
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{{review}}
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Spores gain entry to GI tract -> blood -> muscle -> lie latent. Under right conditions (usually anaerobic following injury) they germinate and bacilli grow. Toxin damages capillaries -> serosanguinous exudate. Muscle necrosis due to gas producing bacteria -> emphysaema and crepitus
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[[Category:Musculoskeletal Diseases - Sheep]][[Category:Liver Diseases - Sheep]][[Category:Musculoskeletal Diseases - Cattle]][[Category:Liver Diseases - Cattle]][[Category:Bacterial Myositis]]
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The bacteria can cause rapid toxaemia resulting in death, however if clinical signs do occur these can include toxaemia, pyrexia, depression, [[Lungs Circulatory - Pathology#Pulmonary oedema|pulmonary oedema]], circulatory collapse
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[[Category:Brian Aldridge reviewing]]
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lameness and swollen hot muscles later becoming cool as necrosis occurs.
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*Pathogenesis:
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**Spores gain entry to GI tract -> blood -> muscle -> lie latent. Under right conditions (usually anaerobic following injury) they germinate and bacilli grow. Toxin damages capillaries -> serosanguinous exudate. Muscle necrosis due to gas producing bacteria -> emphysaema and crepitus
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*Grossly:
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**Early stages
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***At muscle periphery
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***Dark red
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***Distended by serous or serosanguinous exudate
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***Wet cut surface
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**Old stages
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***Centre of lesion is full of gas bubbles, porous, dry, reddish black
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***Rancid odour
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*Histologically:
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**Early stages
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***Separation of myofibres by exudate
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***[[Necrosis - Pathology#Coagulation Necrosis|Coagulative necrosis]]
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***No nuclei
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**Old stage
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***Fragmented muscle fibres separated by gas bubbles
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***Gram positive bacilli may be found in clumps
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[[Category:Sheep]][[Category:To_Do_-_Caz]]

Revision as of 21:35, 18 July 2010

Blackleg myositis (Image sourced from Bristol Biomed Image Archive with permission)
Also known as: Blackquarter



Description

A bacterial disease affecting cattle and sheep caused by Clostridium chauvoei. Latent spores of this organism are deposited in the muscle and liver of ruminants via the circulation resulting in oedematous and crepitant swelling of the muscles.


Signalment

In cattle it is typically beef breeds who are affected particularly animals in good health and good body condition. More frequently occurs in cattle between 6-24 months old but can affect animals of any age. In some animals lesions occur following muscle trauma, which is thought to activate latent spores in the muscle. In sheep, cases typically occur following some form of injury such as shearing cuts, docking or castration.

Diagnosis

Diagnosis is made on clinical signs and muscle biopsy. Affected muscle is black, dry and infiltrated with small bubbles. The lesions can be present in any muscle. Often in sheep, lesions are deep and quite small. Suspected cases can be confirmed using demonstration of C. chauvoei in affected muscle using the fluorescent antibody test.

History and Clinical Signs

Spores gain entry to GI tract -> blood -> muscle -> lie latent. Under right conditions (usually anaerobic following injury) they germinate and bacilli grow. Toxin damages capillaries -> serosanguinous exudate. Muscle necrosis due to gas producing bacteria -> emphysaema and crepitus The bacteria can cause rapid toxaemia resulting in death, however if clinical signs do occur these can include toxaemia, pyrexia, depression, pulmonary oedema, circulatory collapse lameness and swollen hot muscles later becoming cool as necrosis occurs.

  • Pathogenesis:
    • Spores gain entry to GI tract -> blood -> muscle -> lie latent. Under right conditions (usually anaerobic following injury) they germinate and bacilli grow. Toxin damages capillaries -> serosanguinous exudate. Muscle necrosis due to gas producing bacteria -> emphysaema and crepitus
  • Grossly:
    • Early stages
      • At muscle periphery
      • Dark red
      • Distended by serous or serosanguinous exudate
      • Wet cut surface
    • Old stages
      • Centre of lesion is full of gas bubbles, porous, dry, reddish black
      • Rancid odour
  • Histologically:
    • Early stages
    • Old stage
      • Fragmented muscle fibres separated by gas bubbles
      • Gram positive bacilli may be found in clumps
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