Difference between revisions of "Nocardia asteroides"

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***Thoracic, [[Bacterial skin infections - Pathology#bacterial granulomatous dermatitis|cutaneous]] and disseminated forms
 
***Thoracic, [[Bacterial skin infections - Pathology#bacterial granulomatous dermatitis|cutaneous]] and disseminated forms
 
***Cutaneous pyogranulomas: ulcers or granulomatous swellings with discharging fistulae  
 
***Cutaneous pyogranulomas: ulcers or granulomatous swellings with discharging fistulae  
***[[Peritonitis - Pathology#In dogs|peritonitis]]
+
***[[Peritonitis - Cats and Dogs|peritonitis]]
 
***[[Respiratory Bacterial Infections - Pathology#Nocardiosis|pleuritis]] and pyothorax with fever, anorexia and respiratory distress
 
***[[Respiratory Bacterial Infections - Pathology#Nocardiosis|pleuritis]] and pyothorax with fever, anorexia and respiratory distress
 
***Disseminated lesions
 
***Disseminated lesions

Revision as of 14:15, 20 July 2010

    • Found in soil and decaying vegetation - saprophytic
    • Opportunistic infection of immunocompromised animals
    • Infection via inhalation, wounds or teat canal; also ingestion
    • Causes granulomatous lesions in animals
    • Canine nocardiosis:
      • Thoracic, cutaneous and disseminated forms
      • Cutaneous pyogranulomas: ulcers or granulomatous swellings with discharging fistulae
      • peritonitis
      • pleuritis and pyothorax with fever, anorexia and respiratory distress
      • Disseminated lesions
      • Treat with appropriate systemic antibiotics for 6 weeks
    • Cattle: chronic mastitis; abortion
    • Pigs: abortion
    • Sheep, goats, horses: wound infections; mastitis; pneumonia
    • Survives and multiplies in macrophages
    • Superoxide dismutase and catalase as well as a thick peptidoglycan wall prevent activity of phagocytes
    • Chronic, progressive disease
    • Positive modified Ziehl-Neelson
    • Culture on blood agar and incubate under aerobic conditions at 37 degrees centigrade for 10 days
    • White, powdery colonies, adherent to the agar appear after 5 days
    • Subculture onto Sabouraud dextrose agar yields wrinkled, orange colonies
    • Lesions difficult to treat due to resistance of organisms to many antimicrobials (e.g. penicillins)
    • Cell-mediated immunity required