Difference between revisions of "Colitis X"
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==Clinical Signs== | ==Clinical Signs== | ||
| − | + | ||
* Abdominal pain | * Abdominal pain | ||
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* Body temperature may vary from pyrexic to subnormal | * Body temperature may vary from pyrexic to subnormal | ||
* Bowel sounds may be absent | * Bowel sounds may be absent | ||
| + | |||
| + | The clinical signs are similar to those described for other forms of acute- peracute colitis, therefore a number of differential diagnoses may need to be considered. | ||
==Diagnosis== | ==Diagnosis== | ||
| − | Diagnosis is often made post-mortem, where a hyperaemic | + | Diagnosis is often made post-mortem, where a hyperaemic or oedematous caecum and ventral colon may be seen with necrosis of the intestinal in the later stages of the disease. Numerous gram negative bacteria may be identified in the mucosa and submucosa. The intestinal tract may be filled with a foul smelling and watery content. Macroscopic and microscopic findings include signs of disseminated intravascular coagulation and large numbers of bacteria in the devitalized parts of the intestine. |
==Pathology== | ==Pathology== | ||
Revision as of 19:04, 22 July 2010
Description
Colitis X (so-called due to its unknown aetiology) is a peracute and highly fatal disease of horses. Is characterised by severe oedematous colitis, sudden watery diarrhoea and death within 24 hours. A number of possible underlying causes have been described, including drug or parasite hypersensitivity, salmonellosis and high-protein low-cellulose diets. clostridial enterocolitis. Stress (such as surgery or transport) has been reported as a predisposing factor to colitis X.
Signalment
Colitis X affects adult horses, usually between one and ten years old.
Clinical Signs
- Abdominal pain
- Acute onset watery to haemorrhagic diarrhoea
- Tachycardia (Heart rate often greater than 100bpm)
- Dehydration
- Signs relating to hypovolaemic or endotoxic shock, e.g. congested mucous membranes, prolonged capillary refill time, cold extremities.
- Dilated pupils
- Collapse
- Body temperature may vary from pyrexic to subnormal
- Bowel sounds may be absent
The clinical signs are similar to those described for other forms of acute- peracute colitis, therefore a number of differential diagnoses may need to be considered.
Diagnosis
Diagnosis is often made post-mortem, where a hyperaemic or oedematous caecum and ventral colon may be seen with necrosis of the intestinal in the later stages of the disease. Numerous gram negative bacteria may be identified in the mucosa and submucosa. The intestinal tract may be filled with a foul smelling and watery content. Macroscopic and microscopic findings include signs of disseminated intravascular coagulation and large numbers of bacteria in the devitalized parts of the intestine.
Pathology
Treatment
Treatment is often unsuccessful and horses may often require euthanasia. Treatment methods previously described include aggressive fluid therapy with electrolyte replacement, antibiotics and analgesics.
Prognosis
The prognosis is usually poor, with a mortality rate approaching 90-100%.
Prevention
References
- Glenn Songer, J., Trinh, H.T., Dial, S.M., Brazier, J.S., Glock, R.D. (2009) Equine colitis X associated with infection by Clostridium difficile NAP1/027 Journal of Veterinary Diagnostic Investigation 21:377–380
- Diakakis, N. (2008) Equine colitis X Journal of the Hellenic Veterinary Medical Society (Hellenic Veterinary Medical Society) 59:23–28(6)
- Schiefer HB (1981). Equine colitis "X", still an enigma? The Canadian Veterinary Journal. La Revue Vétérinaire Canadienne 22 (5):162–5
- White, N.A., Edwards, G.B. (1999) Handbook of Equine Colic Reed Educational and Professional Publishing Ltd
- Knottenbelt, D.C. A Handbook of Equine Medicine for Final Year Students University of Liverpool
- Edward Robinson, N and Sprayberry, K. A. (2009) Current Therapy In Equine Medicine Sixth edition Saunders Elsevier
- Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial
- Giles, C.J., Urquhart, K.A. and Longstaffe, J.A. (1985) Larval cyathostomiasis (immature trichonema-induced enteropathy): A report of 15 clinical cases Equine Veterinary Journal 17, 196-201
- Murphy, D., Keane, M.P. and Goulding, R. (1997) Cyathostome associated disease in the horse: investigation and management of four cases Equine Veterinary Journal 9 247-252