Difference between revisions of "Colitis X"
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| − | Colitis X (so-called due to its unknown aetiology) is a peracute and highly fatal disease of horses. Is characterised by severe colitis, sudden watery diarrhoea and death within 24 hours. A number of possible underlying causes have been described, including drug or parasite hypersensitivity, stress and transport. | + | ==Description== |
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| + | Colitis X (so-called due to its unknown aetiology) is a peracute and highly fatal disease of horses. Is characterised by severe colitis, sudden watery diarrhoea and death within 24 hours. A number of possible underlying causes have been described, including drug or parasite hypersensitivity, stress and transport. ''Clostridium perfringens'' Type A has been hypothesised to be a cause of Colitis x, and high-protein, low-cellulose diets or antimicrobial treatment may predispose to Clostridial overgrowth. Recently a link has been demonstrated with the current human epidemic strain of ''Clostridum difficile'' (ribotype 027/toxinotype III) clostridial enterocolitis. | ||
==Signalment== | ==Signalment== | ||
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* Tachycardia (Heart rate often greater than 100bpm) | * Tachycardia (Heart rate often greater than 100bpm) | ||
* Dehydration | * Dehydration | ||
| − | * Signs relating to hypovolaemic or endotoxic shock, | + | * Signs relating to hypovolaemic or endotoxic shock, e.g. congested mucous membranes, prolonged capillary refill time, cold extremities. |
* Dilated pupils | * Dilated pupils | ||
* Collapse | * Collapse | ||
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* Bowel sounds may be absent | * Bowel sounds may be absent | ||
| − | The clinical signs are similar to those described for other forms of acute- peracute colitis, particularly | + | |
| + | The clinical signs are similar to those described for other forms of acute- peracute colitis, particularly acute salmonellosis. Rectal examination may often be normal. Other diagnoses that must be considered include grass sickness, acute small intestinal obstructions and intestinal thromboembolic infarctions. | ||
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==Diagnosis and Pathology== | ==Diagnosis and Pathology== | ||
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Colitis x is a diagnosis of exclusion. The above examination findings may be reported combined with an increased plasma urea concentration (greater than 10 mmol/l), increased PCV, leucopaenia, metabolic acidosis, hypokalaemia and hyponatraemia. | Colitis x is a diagnosis of exclusion. The above examination findings may be reported combined with an increased plasma urea concentration (greater than 10 mmol/l), increased PCV, leucopaenia, metabolic acidosis, hypokalaemia and hyponatraemia. | ||
| − | Diagnosis is often made | + | Diagnosis is often made post-mortem, where a hyperaemic or oedematous caecum and ventral colon may be seen with necrosis of the intestinal in the later stages of the disease. Numerous gram negative bacteria may be identified in the mucosa and submucosa. The intestinal tract may be filled with a foul smelling and watery content. Macroscopic and microscopic findings include signs of disseminated intravascular coagulation and large numbers of bacteria in the devitalized parts of the intestine. A green diphtheritic |
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==Treatment== | ==Treatment== | ||
| − | Treatment is often unsuccessful and affected horses usually require euthanasia. If treatment is to be attempted, aggressive fluid therapy and electrolyte replacement must be initiated using a wide bore catheter. Pain is often severe and potent analgesics such as flunixin meglumine are required. The administration of sodium benzyl penicillin may be beneficial as | + | Treatment is often unsuccessful and affected horses usually require euthanasia. If treatment is to be attempted, aggressive fluid therapy and electrolyte replacement must be initiated using a wide bore catheter. Pain is often severe and potent analgesics such as flunixin meglumine are required. The administration of sodium benzyl penicillin may be beneficial as ''Clostridium'' spp are sensitive to this type of antibiotic. |
==Prognosis== | ==Prognosis== | ||
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The prognosis is usually poor, with a mortality rate approaching 90-100%. This may be lower for horses receiving intensive treatment. | The prognosis is usually poor, with a mortality rate approaching 90-100%. This may be lower for horses receiving intensive treatment. | ||
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==References== | ==References== | ||
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| − | [[Category: | + | [[Category:To_Do_-_SophieIgnarski]] |
| + | [[Category:Horse]] | ||
[[Category:Enteritis,_Bacterial]][[Category:Enteritis,_Fibrinous/Haemorrhagic]] | [[Category:Enteritis,_Bacterial]][[Category:Enteritis,_Fibrinous/Haemorrhagic]] | ||
| − | [[Category: | + | [[Category:To_Do_-_Review]] |
Revision as of 19:36, 23 July 2010
 |
This article is still under construction. |
Description
Colitis X (so-called due to its unknown aetiology) is a peracute and highly fatal disease of horses. Is characterised by severe colitis, sudden watery diarrhoea and death within 24 hours. A number of possible underlying causes have been described, including drug or parasite hypersensitivity, stress and transport. Clostridium perfringens Type A has been hypothesised to be a cause of Colitis x, and high-protein, low-cellulose diets or antimicrobial treatment may predispose to Clostridial overgrowth. Recently a link has been demonstrated with the current human epidemic strain of Clostridum difficile (ribotype 027/toxinotype III) clostridial enterocolitis.
Signalment
Colitis X affects adult horses, usually between one and ten years old.
Clinical Signs
- Abdominal pain
- Acute onset watery to haemorrhagic diarrhoea
- Tachycardia (Heart rate often greater than 100bpm)
- Dehydration
- Signs relating to hypovolaemic or endotoxic shock, e.g. congested mucous membranes, prolonged capillary refill time, cold extremities.
- Dilated pupils
- Collapse
- Body temperature may vary from pyrexic to subnormal
- Bowel sounds may be absent
The clinical signs are similar to those described for other forms of acute- peracute colitis, particularly acute salmonellosis. Rectal examination may often be normal. Other diagnoses that must be considered include grass sickness, acute small intestinal obstructions and intestinal thromboembolic infarctions.
Diagnosis and Pathology
Colitis x is a diagnosis of exclusion. The above examination findings may be reported combined with an increased plasma urea concentration (greater than 10 mmol/l), increased PCV, leucopaenia, metabolic acidosis, hypokalaemia and hyponatraemia.
Diagnosis is often made post-mortem, where a hyperaemic or oedematous caecum and ventral colon may be seen with necrosis of the intestinal in the later stages of the disease. Numerous gram negative bacteria may be identified in the mucosa and submucosa. The intestinal tract may be filled with a foul smelling and watery content. Macroscopic and microscopic findings include signs of disseminated intravascular coagulation and large numbers of bacteria in the devitalized parts of the intestine. A green diphtheritic
Treatment
Treatment is often unsuccessful and affected horses usually require euthanasia. If treatment is to be attempted, aggressive fluid therapy and electrolyte replacement must be initiated using a wide bore catheter. Pain is often severe and potent analgesics such as flunixin meglumine are required. The administration of sodium benzyl penicillin may be beneficial as Clostridium spp are sensitive to this type of antibiotic.
Prognosis
The prognosis is usually poor, with a mortality rate approaching 90-100%. This may be lower for horses receiving intensive treatment.
References
- Glenn Songer, J., Trinh, H.T., Dial, S.M., Brazier, J.S., Glock, R.D. (2009) Equine colitis X associated with infection by Clostridium difficile NAP1/027 Journal of Veterinary Diagnostic Investigation 21:377–380
- Diakakis, N. (2008) Equine colitis X Journal of the Hellenic Veterinary Medical Society (Hellenic Veterinary Medical Society) 59:23–28(6)
- Schiefer H.B. (1981). Equine colitis "X", still an enigma? The Canadian Veterinary Journal. La Revue Vétérinaire Canadienne 22 (5):162–5
- White, N.A., Edwards, G.B. (1999) Handbook of Equine Colic Reed Educational and Professional Publishing Ltd
- Knottenbelt, D.C. A Handbook of Equine Medicine for Final Year Students University of Liverpool
- Rose, R.J. and Hodgson, D.R. Manual of Equine Practice Saunders Elsevier
- Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial