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Simple serology is impossible as most cats will have antibody to FECoV.
 
Simple serology is impossible as most cats will have antibody to FECoV.
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However, 4 indicators can be used to cross reference:
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However, 4 indicators can be used for diagnosis:
*High FECoV Ab titres
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*High FECoV Antibody titres
 
*Low albumin:globulin ratio in plasma/ascites (globulin levels rise in FIP)
 
*Low albumin:globulin ratio in plasma/ascites (globulin levels rise in FIP)
 
*High levels of glycoprotein alpha 1-acid glycoprotein (AGP)
 
*High levels of glycoprotein alpha 1-acid glycoprotein (AGP)
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Uveitis, hydrocephalus, neurological symptoms, such as ataxia or seizures and chronic diarrhoea.
 
Uveitis, hydrocephalus, neurological symptoms, such as ataxia or seizures and chronic diarrhoea.
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====Epidemiology====
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*FECoV is '''endemic worldwide''', with the majority of cats showing a subclinical seroconversion
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*'''Orofecal, aerosol, and contact''' transmission
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*Particular concern for '''catteries''' and homes with '''multiple cats'''
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*
      
==Pathology==
 
==Pathology==
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==Control==
 
==Control==
Conventional vaccination is counterproductive as antibody worsens infection however a non-systemic vaccine (Primucell) is available outside the UK
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Conventional vaccination is counterproductive as antibody worsens infection however a non-systemic vaccine (Primucell) is available outside the UK. Replication confined to nasal mucosa, providing local immunity and cell-mediated immunity and it cannot protect cats already infected with FECoV.
**Temperature-sensitive mutant
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Antibody tests are available to certify FECoV-free cat houses.
**Replication confined to nasal mucosa, providing local immunity and cell-mediated immunity
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**Cannot protect cats already infected with FECoV
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**Kittens must be isolated until old enough to vaccinate at 16 weeks
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Antibody tests are available to certify "FECoV-free" cat houses
       
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