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| + | #REDIRECT[[Key-Gaskell Syndrome]] |
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| − | {{cat}}
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| − | {{dog}}
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| − | Also known as Feline Key-Gaskell Syndrome and Feline Autonomic Polygangliopathy.
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| − | Part of a syndrome of generalised autonomic neuropathy. It has been observed throughout Western Europe and The United States.
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| − | ==Signalment==
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| − | * Historically reported most frequently in cats but now also in dogs
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| − | * Usually seen in younger dogs
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| − | * No sex predisposition
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| − | * In a recent study of 65 dogs confirmed as having dysautonomia those raised and housed in rural environments appeared to be at greater risk (56/65 dogs) for dysautonomia than dogs from the city
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| − | * Labrador Retrievers may have a breed predisposition
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| − | ==Description==
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| − | * Degenerative lesions of the autonomic ganglia, spinal cord intermediate grey columns and sympathetic axons
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| − | * Aetiology still largely idiopathic
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| − | ==Diagnosis==
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| − | ===Clinical Signs===
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| − | Those of a generalised autonomic dysfuntion of the gastrointestinal and urinary tracts. Those associated with the oesophagus include:
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| − | * Regurgitation
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| − | * Megaoesophagus
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| − | * Oesophageal hypotmotility
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| − | The most frequent clinical signs associated with the syndrome are depression, anorexia, constipation and regurgitation or vomiting. Incontinence (faecal and urinary) has been observed less frequently.
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| − | ===Physical Examination===
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| − | Findings associated with the GI system include:
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| − | * Dry mucous membranes
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| − | * Intestinal distension
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| − | ===Radiography===
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| − | ====Plain Radiography====
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| − | Oesophageal dilatation may be observed.
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| − | ====Contrast Radiography====
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| − | Oesophageal hypomotility may be evident on barium contrast study.
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| − | ===Histological Findings===
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| − | Chromatolytic degeneration in autonomic ganglia, spinal cord intermediate grey columns and some sympathetic axons.
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| − | ===Pharmalogical Testing===
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| − | * Topical ocular administration of dilute pilocarpine - miosis implies a postive result. However, not all respond. Response is dependent on damage to the postganglionic parasympathetic neuron causing supersensitivity of the iris muscle
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| − | * IV or SC administration of atropine (a parasympatholytic) - lack of increase in heart rate implies a positive result
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| − | * ID administration of histamine - the wheal and flare response may be dampened in those with dysautonomia
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| − | ==Differential Diagnosis==
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| − | There are few differentials on presentation of the many manifestations of the disease. However, early in the course of disease other causes of megaoesophagus need to be considered.
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| − | ==Treatment==
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| − | ===Supportive===
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| − | Including elevated feeding, gastrostomy tube feedings or total paranteral nutrition.
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| − | ===Parasympathomimetic Drugs===
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| − | Some dogs may show minor improvement on initiation of for example, bethanechol, metoclopramide.
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| − | ==Prognosis==
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| − | Guarded to poor. Recovery rates in the cat are reported as 20-40%, however this may take 2-12 months. In the dog recovery rates are lower. Despite recovery many are also left with residual impairment including intermittent regurgitation.
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| − | ==References==
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| − | * Hall J.H, Wimpson J. W. and Williams D.A, (2005), Disorders of the Pharynx and Oesophagus, in BSAVA Manual of Canine and Feline Gastroenterology, 2nd Edition, British Small Animal Association, Gloucester, pp 142-143
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| − | * Harkin K.R, Andrews G.A, Nietfeld J.C, (2002), Dysautonomia in dogs: 65 cases (1993–2000) J Am Vet Med Assoc, Mar 1, 220(5): pp. 633-9
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