Granulation Tissue

Granulation tissue (Courtesty of BioMed Archive)

• Is completlely different to granulomatous inflammation, despite the similarity in name!
• Occurs on the surface of the skin where large areas of the epithelium have been lost.
• Makes up the lining of sinus tracts discharging from deeper lesions.
• Takes its name from the gross appearance of the small vessels which appear at the surface.
  • Look like red granules.
  • These vessels supply inflammatory cells, mainly neutrophils, to the infected surface.
• The most frequent example in domestic animals is the formation of excessive granulation tissue on the legs of horses with poorly healing wounds.
  • "Proud flesh"
• Ulcers and open wounds may heal by granulation.