Granulation Tissue

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Granulation tissue (Courtesty of BioMed Archive)
  • Is completlely different to granulomatous inflammation, despite the similarity in name!
  • Occurs on the surface of the skin where large areas of the epithelium have been lost.
  • Makes up the lining of sinus tracts discharging from deeper lesions.
  • Takes its name from the gross appearance of the small vessels which appear at the surface.
    • Look like red granules.
    • These vessels supply inflammatory cells, mainly neutrophils, to the infected surface.
  • The most frequent example in domestic animals is the formation of excessive granulation tissue on the legs of horses with poorly healing wounds.
    • "Proud flesh"
  • Ulcers and open wounds may heal by granulation.