Difference between revisions of "Photosensitisation"
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| + | ==Description== | ||
Photosensitisation is an abnormal reaction of the skin to sunlight due to the presence of a photodynamic agent in the dermis. It is | Photosensitisation is an abnormal reaction of the skin to sunlight due to the presence of a photodynamic agent in the dermis. It is | ||
primarily a condition of sheep, cattle and horses but other species may also be susceptible. | primarily a condition of sheep, cattle and horses but other species may also be susceptible. | ||
| − | The condition can be divided into two categories | + | The condition can be divided into two categories, primary and secondary photosensitisation. Primary photosensitisation occurs due to the ingestion of lush green plants containing photodynamic agents. Secondary (hepatogenous) photosensitisation is the most commmon type of photosensitivity seen in animals and occurs as a result of liver or bile duct damage. The photosensitising agent, phylloerythrin (a breakdown product of chlorophyll) accumulates in the blood, body tissues and skin due to insufficient conjugation and excretion by the liver. This accumulation in the skin leads to absorption and release of UV light, leading to a phototoxic reaction. |
==Clinical signs== | ==Clinical signs== | ||
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The condition is characterised by clearly demarcated 'sunburn-like' lesions that are confined to unpigmented or hairless areas of the skin. The nose, lips, ears, muzzle and udder are commonly affected areas. In the acute stages, the affected area(s) becomes erythematous and oedematous with exudation and crust formation. Animals may be pruritic or painful. Other clinical signs may include swollen lips or muzzle, tachypnoea, tachycardia, diarrhoea and salivation. | The condition is characterised by clearly demarcated 'sunburn-like' lesions that are confined to unpigmented or hairless areas of the skin. The nose, lips, ears, muzzle and udder are commonly affected areas. In the acute stages, the affected area(s) becomes erythematous and oedematous with exudation and crust formation. Animals may be pruritic or painful. Other clinical signs may include swollen lips or muzzle, tachypnoea, tachycardia, diarrhoea and salivation. | ||
| − | If the photosensitisation is secondary (hepatogenous), | + | If the photosensitisation is secondary (hepatogenous), icterus may be present. Other signs may include those consistent with hepatic encephalopathy such as head-pressing, circling, and behavioural changes. |
==Diagnosis== | ==Diagnosis== | ||
| − | The history and clinical signs of affected animals are important in order to differentiate whether the condition is primary or secondary. In the case of primary photosensitisation there is often a history of exposure to plants containing photodynamic agents. Alternatively, there may be a history of administration of drugs such as phenothiazines, sulphonamides or tetracyclines | + | The history and clinical signs of affected animals are important in order to differentiate whether the condition is primary or secondary. In the case of primary photosensitisation there is often a history of exposure to plants containing photodynamic agents such as St. John's Wort or clover. Alternatively, there may be a history of administration of drugs such as phenothiazines, sulphonamides or tetracyclines. Signs of liver disease are usually absent. |
| − | In animals affected by secondary photosensitisation the classic skin lesions | + | In contrast, in animals affected by secondary photosensitisation the classic skin lesions are accompanied by the signs of liver disease listed above. Serum biochemistry often reveals increased liver enzymes (ALP, GGT, SDH and ALT) but bilirubin and bile acid concentrations are usually normal. Ultrasonography may be useful in evaluating the hepatic structure and identifying pathological changes indicative of secondary disase. Definitive diagnosis may be obtained by liver biopsy. |
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==Treatment== | ==Treatment== | ||
| − | Affected animals should be removed from pasture suspected to contain the photodynamic agent. Any drugs | + | Affected animals should be removed from pasture suspected to contain the photodynamic agent. Any drugs given at the time of the condition developing should be stopped. Affected animals should only be allowed access to grazing at night. Anti-inflammatory drugs such as flunixin meglumine and topical steroid creams may be useful to decrease the severity of cutaneous lesions in the acute stage of the disease. |
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| − | Anti-inflammatory drugs such as flunixin meglumine and topical steroid creams may be useful to decrease the severity of cutaneous lesions in the acute stage of the disease | ||
| − | If the animal is affected by secondary photosensitisation, | + | If the animal is affected by secondary photosensitisation, a low-protein, high-energy diet is recommended such as beet pulp. If skin necrosis is severe, surgical debridement may be required. |
==Prognosis== | ==Prognosis== | ||
| − | In general the prognosis is favourable for primary photosensitisation | + | In general the prognosis is favourable for primary photosensitisation and poor for secondary photosensitisation. |
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==References== | ==References== | ||
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* Lavoie, J. P., (2009) '''Blackwell's five-minute veterinary consult: equine''' ''John Wiley & Sons'' | * Lavoie, J. P., (2009) '''Blackwell's five-minute veterinary consult: equine''' ''John Wiley & Sons'' | ||
* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial'' | * Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial'' | ||
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[[Category:Liver_-_General_Pathology]] | [[Category:Liver_-_General_Pathology]] | ||
| − | [[Category: | + | [[Category:To_Do_-_SophieIgnarski]] |
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Revision as of 14:43, 10 August 2010
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This article is still under construction. |
Description
Photosensitisation is an abnormal reaction of the skin to sunlight due to the presence of a photodynamic agent in the dermis. It is primarily a condition of sheep, cattle and horses but other species may also be susceptible.
The condition can be divided into two categories, primary and secondary photosensitisation. Primary photosensitisation occurs due to the ingestion of lush green plants containing photodynamic agents. Secondary (hepatogenous) photosensitisation is the most commmon type of photosensitivity seen in animals and occurs as a result of liver or bile duct damage. The photosensitising agent, phylloerythrin (a breakdown product of chlorophyll) accumulates in the blood, body tissues and skin due to insufficient conjugation and excretion by the liver. This accumulation in the skin leads to absorption and release of UV light, leading to a phototoxic reaction.
Clinical signs
The condition is characterised by clearly demarcated 'sunburn-like' lesions that are confined to unpigmented or hairless areas of the skin. The nose, lips, ears, muzzle and udder are commonly affected areas. In the acute stages, the affected area(s) becomes erythematous and oedematous with exudation and crust formation. Animals may be pruritic or painful. Other clinical signs may include swollen lips or muzzle, tachypnoea, tachycardia, diarrhoea and salivation.
If the photosensitisation is secondary (hepatogenous), icterus may be present. Other signs may include those consistent with hepatic encephalopathy such as head-pressing, circling, and behavioural changes.
Diagnosis
The history and clinical signs of affected animals are important in order to differentiate whether the condition is primary or secondary. In the case of primary photosensitisation there is often a history of exposure to plants containing photodynamic agents such as St. John's Wort or clover. Alternatively, there may be a history of administration of drugs such as phenothiazines, sulphonamides or tetracyclines. Signs of liver disease are usually absent.
In contrast, in animals affected by secondary photosensitisation the classic skin lesions are accompanied by the signs of liver disease listed above. Serum biochemistry often reveals increased liver enzymes (ALP, GGT, SDH and ALT) but bilirubin and bile acid concentrations are usually normal. Ultrasonography may be useful in evaluating the hepatic structure and identifying pathological changes indicative of secondary disase. Definitive diagnosis may be obtained by liver biopsy.
Treatment
Affected animals should be removed from pasture suspected to contain the photodynamic agent. Any drugs given at the time of the condition developing should be stopped. Affected animals should only be allowed access to grazing at night. Anti-inflammatory drugs such as flunixin meglumine and topical steroid creams may be useful to decrease the severity of cutaneous lesions in the acute stage of the disease.
If the animal is affected by secondary photosensitisation, a low-protein, high-energy diet is recommended such as beet pulp. If skin necrosis is severe, surgical debridement may be required.
Prognosis
In general the prognosis is favourable for primary photosensitisation and poor for secondary photosensitisation.
References
- Gupta, R. C., (2007) Veterinary Toxicology: basic and clinical principles Academic Press
- Haskell, S. R. R., (2008) Blackwell's five-minute veterinary consult: ruminant John Wiley & Sons
- Lavoie, J. P., (2009) Blackwell's five-minute veterinary consult: equine John Wiley & Sons
- Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial