Megacolon

Description

Megacolon is a state of permanently increased diameter of the large bowel. This change in intestinal structure leads to abnormal function, including reduced colonic motility and chronic constipation. The condition most commonly occurs in cats and dogs, but pigs can also be afffected. White foals suffering congenital colonic agangliosis, an autosomal recessive trait, may develop secondary megacolon.

In small animals, megacolon may be congenital or acquired, which may be idiopathic. Although well described in human medicine, congenital megacolon has not been convincingly described in animals despite first being reported in 1988¹. In man, Hirschsprung's disease manifests at a very young age is caused by an absence of inhibitory neurons in Meissner’s submucosal plexus and Auerbach’s myenteric plexus in the distal colon or rectum². This gives persistent smooth muscle contraction in the affected region and proximal dilation of the colon. A similar pathogenesis is proposed in cats.

Acquired megacolon is more common than the congenital form, and in cats this is most often idiopathic. The true cause of "idiopathic" megacolon is thought to be an intrinsic defect in colonic smooth muscle function³. Aquired megacolon can occur in both cats and dogs as a sequel to any disease or lesion that interferes with normal defecation: faecal retention caused dilatation of the colon and impairs colonic motility. Causes could include neuromuscular abnormalities (spinal cord disease, intervertebral disk disease, dysautonomia, trauma), metabolic disorders (severe dehydration, hypokalaemia), drug therapy (vincristine, anticholinergics, barium), mechanical obstruction (pelvic fracture malunion, foreign bodies, stricture, anal/rectal atresia) and conditions causeing dyschezia (anal sacculitus, perianal fistula, trauma preventing posturing, procititis). After megacolon has persisted for several months, it is unlikely that normal colonic motility will be restored after resolution of the underlying cause. In many cases, the aetiology of megacolon is not determined.

Signalment

Manx Cat. Source: Wikimedia Commons; Author: Jonik (2004)

Megacolon much more commonly affects cats than dogs, but any age, breed or sex of animal may develop aquired megacolon. Idiopathic megacolon is more common in middle-aged to older cats, and there is some evidence for an increased risk in Manx cats due to a sacral spinal cord deformity.

Diagnosis

Clinical Signs

Idiopathic megacolon is likely to be a long-term, recurring problem, with clinical sgns presenting over months to years. In acquired megacolon, signs can be acute or chronic in onset.

The primary sign of megacolon is constpation or obstipation (severe constipation caused by intestinal obstruction). Animals suffer tenesmus when defaecating and produce little or no faeces. Faeces that is expelled is very hard and dry, and animals defaecate less frequently. After prolonged tenesmus, a small amount of often mucoid diarrhoea may be expelled. Vomiting, anorexia and weight loss are other key features.

On clinical examination, an enlarged colon packed with hard faeces is palpated within the abdomen. The animal may be dehydrated, and the hair coat rough. Digital anorectal examination is necessary, and confirms faecal impaction as well as potentially revealing an underlying obstructive cause.

Laboratory Tests

. A complete neurological examination and routine laboratory evaluation (haematology and biochemistry, serum electrolytes and urinalysis) should be carried out. Thyroid function should be checked in younger cats, as obstipation can be seen with juvenile-onset hypothyroidism.

Diagnostic Imaging

Plain radiographs should be taken of the abdomen and pelvis, with subsequent contrast studies and ultrasound examination if required.

References

1. Rosin, E et al (1988) Subtotal colectomy for treatment of chronic constipation associated with idiopathic megacolon in cats: 38 cases (1979-1895). Journal of the American Veterinary Medical Association, 193, 850-853.
2. Pratschke, K (2005) Surgical disease of the colon and rectum in small animals. In Practice, 27, 354-362.
3. Washabau, R J and Stalis, I H (1996) Effects of cisapride on feline colonic smooth muscle function. American Journal of Veterinary Research, 57, 541-546.