Difference between revisions of "Extrinsic Allergic Bronchio-Alveolitis"
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(Created page with "*Synonym: '''Bovine Farmers Lung''' *Arises due to repeated inhalation of spores of thermophilic actinomycetes in mouldy hay (''Micropolyspora faeni a...") |
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**Associated thickening of the alveolar septae | **Associated thickening of the alveolar septae | ||
**In severe and chronic disease, the lesions can progress to severe interstitial fibrosis and type II hyperplasia | **In severe and chronic disease, the lesions can progress to severe interstitial fibrosis and type II hyperplasia | ||
| − | **In extreme cases, vascular compromise may -> [[Pulmonary | + | **In extreme cases, vascular compromise may -> [[Lungs Circulatory - Pathology#Pulmonary hypertension|'''pulmonary hypertension''']] -> [[Cor Pulmonale|'''cor pulmonale''']] |
[[Category:Allergic Respiratory Diseases]] | [[Category:Allergic Respiratory Diseases]] | ||
| − | [[Category: | + | [[Category:Cattle]] |
| − | [[Category:To Do - Blood | + | [[Category:To Do - Blood]] |
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Revision as of 14:19, 11 August 2010
- Synonym: Bovine Farmers Lung
- Arises due to repeated inhalation of spores of thermophilic actinomycetes in mouldy hay (Micropolyspora faeni and Thermactinomyces vulgaris)
- Can be experimentally reproduced by repeated exposure to M. faeni aerosols
- Disease primarily of housed animals in winter
- Spores can penetrate to the level of terminal bronchioles and alveoli throughout the lung
- Pathogenesis results from a type III (Arthus) hypersensitivity reaction to the inhaled fungal spores
- Macroscopically:
- Lungs appear normal however on close inspection, numerous small grey nodules representing lymphoid reaction are evident
- Histologically:
- Lymphocytic/plasmacytic bronchitis/ bronchiolitis
- Associated thickening of the alveolar septae
- In severe and chronic disease, the lesions can progress to severe interstitial fibrosis and type II hyperplasia
- In extreme cases, vascular compromise may -> pulmonary hypertension -> cor pulmonale