Difference between revisions of "Category:Primary Innate Immunity Deficiencies"

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(Created page with "===Deficiencies of Innate Immunity=== [[Image:Grey Collie Syndrome.jpg|thumb|right|150px|Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melto...")
 
 
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===Deficiencies of Innate Immunity===
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[[Image:Grey Collie Syndrome.jpg|thumb|right|150px|Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melton]]
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|pagetitle =Primary Innate Immunity Deficiencies
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====Canine Cyclic Haematopoiesis====
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*Also called '''Grey Collie Syndrome'''
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*Autosomal recessive
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*Insertion mutation in AP3B1 gene
 
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*Diluted grey coat colour, stunted growth, poor wound healing
 
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*Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from [[Bone Marrow - Anatomy & Physiology|bone marrow]]
 
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*Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
 
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**E.g. pyrexia, [[Diarrhoea|diarrhoea]], gingivitis and arthritis
 
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*Puppies can be distinguished from other litter mates by the diluted grey colouring
 
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*Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age
 
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*Affected animals rarely live beyond 2-3 years with most puppies dying within a few weeks of birth
 
  
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====Canine Leukocyte Adhesion Deficiency (CLAD)====
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<categorytree mode=pages>Primary Innate Immunity Deficiencies</categorytree>
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*Occurs in Irish Setters
 
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*Missence mutation of -Cys-36-Ser- in CD18 molecule
 
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**CD18 is required for [[Neutrophils|neutrophil]] migration and phagocytosis
 
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*Recurrent bacterial infection
 
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*Neutrophilia ([[Neutrophils|neutrophils]] remain in the blood and are unable to fight infection in the tissue)
 
  
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====Bovine Leukocyte Adhesion Deficiency (BLAD)====
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|logo = Immature MDDC.png
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*Occurs in Holstein cattle
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*Missence mutation of -Asp-128-Gly in CD18 molecule
 
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*Recurrent infection, e.g. pneumonia
 
  
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[[Category:Primary Im
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[[Category:Primary Immunodeficiency|A]]

Latest revision as of 14:23, 12 August 2010

Primary Innate Immunity Deficiencies

Content

▼ Primary Innate Immunity Deficiencies
  Bovine Leukocyte Adhesion Deficiency
  Canine Cyclic Haematopoiesis
  Canine Leukocyte Adhesion Deficiency

Pages in category "Primary Innate Immunity Deficiencies"

The following 3 pages are in this category, out of 3 total.

B

C

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