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→Clinical Signs
* The prognosis is poor for dogs with CNS involvement.
* The prognosis is poor for dogs with CNS involvement.
*'''Clinical signs''':
**Mucopurulent oculonasal discharge
**Keratitis
**[[Lungs Inflammatory - Pathology#Interstitial pneumonia|Interstitial pneumonia]]
**Severe clinical pneumonia follows secondary infection with [[Bordetella bronchiseptica|''Bordetella bronchiseptica'']]
**Smelly sometimes bloody diarrhoea
**Eruptions on the skin including hyperkeratosis of the nose and pads (hardpad)
**[[PNS Repsonses to Injury - Pathology#Segmental Demyelination|Demyelination]] (especially in cerebellum) -> incoordination or muscle tremors -> paralysis and coma or convulsions -> death
**Encephalitis
**Secondary pyogenic infections associated with immunosuppression and damage to epithelia
**Recovered animals may have persistent or spasmodic chorea
**The severity of the disease may vary; if enough neutralising antibody develops in the early stages, the virus maybe kept restricted largely to the lymph nodes
*Variable mortality depending on virulence
*May occur '''subclinically'''
*Involvement of central nervous system generally results in death
*Can contribute to [[Canine Infectious Tracheobronchitis|Infectious Canine Tracheitis]]
*May be involved in [[Pancreatitis, Chronic Interstitial|chronic interstitial pancreatitis]]
*May cause [[Bones Developmental - Pathology#Retention of elongated primary trabeculae|growth retardation lattice]]
*May also trigger latent [[Toxoplasma|Toxoplasmosis]] due to suppressing effect on lymphoid tissue
===Laboratory Tests===
===Laboratory Tests===