Difference between revisions of "Sendai Virus"
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m (Text replace - "Category:To_Do_-_Viruses" to "Category:To_Do_-_Clinical/Viruses") |
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| Line 3: | Line 3: | ||
*Most mice show no symptoms due to maternal antibodies | *Most mice show no symptoms due to maternal antibodies | ||
*But minor respiratory lesions may invalidate carcinogenic or toxicological studies | *But minor respiratory lesions may invalidate carcinogenic or toxicological studies | ||
| − | *Immunological studies also confused due to virus activating [[ | + | *Immunological studies also confused due to virus activating [[Natural Killer cells|NK cells]] via high circulating [[Interferons|IF]] 3-4 days post-infection |
*Control achieved by: | *Control achieved by: | ||
**Purchasing '''specific pathogen free (SPF)''' mice | **Purchasing '''specific pathogen free (SPF)''' mice | ||
Revision as of 16:35, 13 August 2010
Murine Parainfluenza - 1 (Sendai Virus)
- Endemic in many mouse colonies
- Most mice show no symptoms due to maternal antibodies
- But minor respiratory lesions may invalidate carcinogenic or toxicological studies
- Immunological studies also confused due to virus activating NK cells via high circulating IF 3-4 days post-infection
- Control achieved by:
- Purchasing specific pathogen free (SPF) mice
- Kill whole colony in an outbreak -> disinfection -> formalin fumigation