Changes

==Clinical signs and features==

==Clinical signs and features==

===Birds===

===Birds===

In avian species the disease manifests as a diffuse infection of the air sacs. Three forms of the disease have been reported; a diffuse infection of the air sacs; a diffuse pneumonic form and a nodular form involving the lungs. In chicks and poults the disease is known as 'brooder pneumonia' and may affect many birds in a flock. Animals become infected due to inhalation of spores from contaminated feed or litter. Clinical signs include dyspnoea, diarrhoes, listlessness, pyrexia, loss of appetite and loss of condition. Seizures and torticollis may occasionally occur if infection disseminates to the brain.

Three forms of the disease have been reported in avian species; a diffuse infection of the air sacs; a diffuse pneumonic form and a nodular form involving the lungs. In chicks and poults the disease is known as 'brooder pneumonia' and may affect many birds in a flock. Animals become infected due to inhalation of spores from contaminated feed or litter. Clinical signs include dyspnoea, diarrhoes, listlessness, pyrexia, loss of appetite and loss of condition. Seizures and torticollis may occasionally occur if infection disseminates to the brain.

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===Cattle===

===Cattle===

Aspergillosis has a number of clinical manifestations in the cow including mastitis, placentitis, ocular infections and mycotic pneumonia and diarrhoea with systemic diseas occurring in some cases. Abortion in the second or third trimester of pregnancy has also been described. In the case of pulmonic disease, clinical signs may include pyrexia, cough, dyspnoea and tachypnoea but may be limited to vague signs such as weight loss or mild respiratory disease. In aborting cattle, the foetus and placenta are retained and foetal lesions such as bronchopneumonia and dermatitis may be seen.

Aspergillosis has a number of clinical manifestations in the cow including mastitis, placentitis, diarrhoea ocular infection and mycotic pneumonia. Abortion in the second or third trimester of pregnancy has also been described. In the case of pulmonic disease, clinical signs may include pyrexia, cough, dyspnoea and tachypnoea but may be limited to vague signs such as weight loss or mild respiratory disease. In aborting cattle, the foetus and placenta are retained and foetal lesions such as bronchopneumonia and dermatitis may be seen. Mastitic cows may display depression, weight loss and pyrexia with purulent mammary secretions and a hot, swollen udder.

Lesions are usually up to 2mm in diameter and contain asteroid bodies with a germinated spore in the centre. Acute infection causes miliary lesions and chronic infections causes granulomatous and calcified lesions.

===Horses===

===Horses===

==Treatment==

==Treatment==

In dogs, the treatment of choice is topical application of the anti-fungal agent Clotrimazole. It is admnistered for one hour under general anaesthetic via indwelling catheters placed in the frontal sinus. Several treatments may be required. For cases that are non-responsive to Clotrimazole, treatment with Enilconazole may be attempted but this is associated with a higher complication rate  

In dogs, the treatment of choice is topical application of the anti-fungal agent Clotrimazole. It is admnistered for one hour under general anaesthetic via indwelling catheters placed in the frontal sinus. Several treatments may be required. For cases that are non-responsive to Clotrimazole, treatment with Enilconazole may be attempted but this is associated with a higher complication rate.

==Prognosis==

==Prognosis==