Difference between revisions of "Innate Immunity to Viruses"

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[[Image:Innate viral response.jpg|thumb|right|150px|Innate response to dsRNA - B. Catchpole, RVC 2008]]
 
[[Image:Innate viral response.jpg|thumb|right|150px|Innate response to dsRNA - B. Catchpole, RVC 2008]]
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==Introduction==
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Because viruses invade host cells to take over a host's cellular machinery, the innate system has a more difficult time detecting viruses as foreign agents. However, there is a give-away element of the viral attack that the innate system can recognize: the '''double-stranded RNA''' (dsRNA) produced by a virus in its replication phase. Because mammalian cells only ever produce single-stranded RNA, the presence of dsRNA signals a foreign intruder. dsRNA can be detected by TLR-3R on the cell surface or intracellularly by the presence of dsRNA-dependent protein kinase.   
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Because viruses invade host cells to take over a host's cellular machinery, the [[Innate Immune System - Introduction|innate system]] has a more difficult time detecting [[viruses]] as foreign agents. However, there is a give-away element of the viral attack that the innate system can recognize: the '''double-stranded RNA''' (dsRNA) produced by a virus in its replication phase. Because mammalian cells only ever produce single-stranded RNA, the presence of dsRNA signals a foreign intruder. dsRNA can be detected by TLR-3R on the cell surface or intracellularly by the presence of dsRNA-dependent protein kinase.   
 
  
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==Interferons==
 
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The innate response to viral attack also depends on the presence of '''Type-1 Interferons''', which are produced by all cells on recognition of a viral attack. [[Interferons]] serve to increase degradation of mRNA, inhibit protein synthesis, and increase the effectiveness of the adaptive response by increasing antigen presentation to antibody. 
 
  
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==Natural Killer cells==
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The innate response to viral attack also depends on the presence of '''Type-1 Interferons''', which are produced by all cells on recognition of a viral attack. Interferons serve to increase degradation of mRNA, inhibit protein synthesis, and increase the effectiveness of the adaptive response by increasing antigen presentation to antibody.
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Lastly, the final line of defense for the innate response to viruses lies in the actions of [[Natural Killer cells|'''Natural Killer (NK) cells''']].  These warriors monitor the production of [[Major Histocompatability Complexes|MHC]] (Major Histocompatibility Complex) on the surface of cells, which is produced as part of the adaptive response. A cell whose cellular machinery is compromised by viral infection will experience a drop in the amount of MHC it produces. When a cell's MHC production drops, NK cells trigger '''apoptosis''', otherwise known as ''programmed cell death'', in these cells. Inducing apoptosis stops the use of replication machinery of the infected cells being hijacked by the viruses for their replication. Once a cell has undergone apoptosis, it's cleared by [[macrophages]] through the process of [[Phagocytosis|phagocytosis]], killing the virus inside. As such, this is a non-specific targeting based simply on the ability of a cell to function normally, which also lends them to playing a role in targeting malignant cells. NK cells are incapable of directly targeting viral infection.
 
  
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{{Learning
 
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|flashcards = [[Innate Immunity Flashcards]]
 
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}}
 
  
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<br><br>
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Lastly, the final line of defense for the innate response to viruses lies in the actions of [[Natural Killer cells|'''Natural Killer (NK) cells''']].  These warriors monitor the production of [[Major Histocompatability Complexes|MHC]] (Major Histocompatibility Complex) on the surface of cells, which is produced as part of the adaptive response.  A cell whose cellular machinery is compromised by viral infection will experience a drop in the amount of MHC it produces.  When a cell's MHC production drops, NK cells are triggered to phagocytose these cells.  As such, this is a non-specific targeting based simply on the ability of a cell to function normally, which also lends them to playing a role in targeting malignant cells.  NK cells are incapable of directly targeting viral infection.
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{{Robert J Francis
 
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|date = May 10, 2012}}
 
  
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{{Jim Bee 2007}}
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<big>'''Also see [[Immunity to Viruses]]'''</big>
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[[Category:To Do - Blood]][[Category:To Do - Clinical]]
 
[[Category:Innate Immune System]]
 
[[Category:Innate Immune System]]
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[[Category:Robert J Francis reviewed]]
 

Revision as of 10:55, 20 August 2010

Innate response to dsRNA - B. Catchpole, RVC 2008

Because viruses invade host cells to take over a host's cellular machinery, the innate system has a more difficult time detecting viruses as foreign agents. However, there is a give-away element of the viral attack that the innate system can recognize: the double-stranded RNA (dsRNA) produced by a virus in its replication phase. Because mammalian cells only ever produce single-stranded RNA, the presence of dsRNA signals a foreign intruder. dsRNA can be detected by TLR-3R on the cell surface or intracellularly by the presence of dsRNA-dependent protein kinase.


The innate response to viral attack also depends on the presence of Type-1 Interferons, which are produced by all cells on recognition of a viral attack. Interferons serve to increase degradation of mRNA, inhibit protein synthesis, and increase the effectiveness of the adaptive response by increasing antigen presentation to antibody.


Lastly, the final line of defense for the innate response to viruses lies in the actions of Natural Killer (NK) cells. These warriors monitor the production of MHC (Major Histocompatibility Complex) on the surface of cells, which is produced as part of the adaptive response. A cell whose cellular machinery is compromised by viral infection will experience a drop in the amount of MHC it produces. When a cell's MHC production drops, NK cells are triggered to phagocytose these cells. As such, this is a non-specific targeting based simply on the ability of a cell to function normally, which also lends them to playing a role in targeting malignant cells. NK cells are incapable of directly targeting viral infection.

Also see Immunity to Viruses

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