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====Hydrocortisone aceponate====
 
====Hydrocortisone aceponate====
Hydrocortisone aceponate is a novel topical
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Hydrocortisone aceponate is a topical glucocorticoid that relieves pruritus. The topical administration and the fact that hydrocotisone aceponate is metabolised in the dermis means that many of the traditional side-effects of glucocorticoid therapy are avoided<sup>4</sup>. The product is potent, and rapidly exerts its effects following application.  
diester glucocorticoid for the treatment of pruritus
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in dogs. Topical diester glucocorticoids overcome
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Early studies (unpublished) demonstrated good
many of the adverse effects traditionally
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associated with systemic or topical glucocorticoid
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therapy. They are rapidly absorbed and exert
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potent anti-inflammatory effects within the
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epidermis and superficial dermis. Metabolism
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within the dermis, however, ensures that very
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little active compound reaches deeper tissues
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and the circulation, minimizing skin thinning
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and systemic effects. The topical formulation,
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furthermore, eases topical administration. The
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small dose volume, very small droplet size and
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volatile carrier help to ensure quick and easy
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application, penetration of even haired skin and
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rapid drying with minimal cutaneous after
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effects. The spray is formulated such that two
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sprays from 10 cm away will penetrate the coat
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and treat a 10 x 10 cm (i.e. palm sized area of
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skin). Early studies (unpublished) demonstrated good
   
efficacy and safety in short term treatment of
 
efficacy and safety in short term treatment of
 
various pruritic disorders in dogs including
 
various pruritic disorders in dogs including
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