Difference between revisions of "Erythropoietic Porphyria"
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Also known as: '''''Congenital Pink Tooth — Porphyria | Also known as: '''''Congenital Pink Tooth — Porphyria | ||
| − | == | + | ==Description== |
Congenital erythropoietic porphyria is a rare disease that affects cattle, cats and occasionally pigs. It occurs due to a defect in the metabolism of the haem group of haemoglobin leading to the deposition of pigment molecules in the skin and teeth. | Congenital erythropoietic porphyria is a rare disease that affects cattle, cats and occasionally pigs. It occurs due to a defect in the metabolism of the haem group of haemoglobin leading to the deposition of pigment molecules in the skin and teeth. | ||
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The deposition of haem degradation products in the [[:Category:Teeth - Anatomy & Physiology|teeth]] results in red/pink discolouration, hence the name '''pink tooth'''. | The deposition of haem degradation products in the [[:Category:Teeth - Anatomy & Physiology|teeth]] results in red/pink discolouration, hence the name '''pink tooth'''. | ||
| − | The pigment products which are deposited in the skin cause secondary [[Photosensitisation|'''photosensitisation''']]. This manifests as a crusting dermatitis in non-pigmented areas of the skin which are exposed to sunlight. Cattle are often affected over their face, around their eyes and over any white patches of the body. | + | The pigment products which are deposited in the skin cause secondary [[Photosensitisation|'''photosensitisation''']]. This manifests as a crusting dermatitis in non-pigmented areas of the skin which are exposed to sunlight. Cattle are often affected over their face, around their eyes and over any white patches of the body. |
| − | Some types of porphyria may cause | + | Some types of porphyria may cause '''anaemia''' in Siamese cats. |
===Differential Diagnoses=== | ===Differential Diagnoses=== | ||
| − | Discolouration of single teeth is more likely to be caused by '''pathological processes in the oral cavity''', including tooth root abscesses and pulpitis. '''Fluorosis''' may cause chalky mottling (odontodystrophy) and yellow/brown discolouration of teeth in cattle that are exposed to cement works effluent. | + | Discolouration of single teeth is more likely to be caused by '''pathological processes in the oral cavity''', including tooth root abscesses and pulpitis. '''Fluorosis''' may cause chalky mottling (odontodystrophy) and yellow/brown discolouration of teeth in cattle that are exposed to cement works effluent. |
===Pathology=== | ===Pathology=== | ||
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==Treatment== | ==Treatment== | ||
| − | There is no specific treatment for porphyria. Affected animals should be kept out of sunlight. | + | There is no specific treatment for porphyria. Affected animals should be kept out of sunlight. |
==Prognosis== | ==Prognosis== | ||
Affected animals may suffer from severe burns if they exposed to sunlight but they may otherwise live normally. | Affected animals may suffer from severe burns if they exposed to sunlight but they may otherwise live normally. | ||
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==References== | ==References== | ||
Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine''' (6th edition, volume 2) Elsevier Saunders Company | Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine''' (6th edition, volume 2) Elsevier Saunders Company | ||
| − | + | [[Category:Teeth - Developmental Pathology]][[Category:Cattle]][[Category:Cat]][[Category:Pig]] | |
| − | + | [[Category:To_Do_-_James]][[Category:To Do - Review]] | |
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Revision as of 16:48, 3 September 2010
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This article is still under construction. |
Also known as: Congenital Pink Tooth — Porphyria
Description
Congenital erythropoietic porphyria is a rare disease that affects cattle, cats and occasionally pigs. It occurs due to a defect in the metabolism of the haem group of haemoglobin leading to the deposition of pigment molecules in the skin and teeth.
Diagnosis
Clinical Signs
The deposition of haem degradation products in the teeth results in red/pink discolouration, hence the name pink tooth.
The pigment products which are deposited in the skin cause secondary photosensitisation. This manifests as a crusting dermatitis in non-pigmented areas of the skin which are exposed to sunlight. Cattle are often affected over their face, around their eyes and over any white patches of the body.
Some types of porphyria may cause anaemia in Siamese cats.
Differential Diagnoses
Discolouration of single teeth is more likely to be caused by pathological processes in the oral cavity, including tooth root abscesses and pulpitis. Fluorosis may cause chalky mottling (odontodystrophy) and yellow/brown discolouration of teeth in cattle that are exposed to cement works effluent.
Pathology
At post-mortem examination, the bones are found to have the same pink/brown discolouration as the teeth.
Treatment
There is no specific treatment for porphyria. Affected animals should be kept out of sunlight.
Prognosis
Affected animals may suffer from severe burns if they exposed to sunlight but they may otherwise live normally.
References
Ettinger, S.J, Feldman, E.C. (2005) Textbook of Veterinary Internal Medicine (6th edition, volume 2) Elsevier Saunders Company