Changes

==Dendritic Cells==

==Dendritic Cells==

[[Image:Lineages of dendritic cells.jpg|thumb|right|300px|Diagram showing the 2 Lineages of dendritic cells - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]

[[Image:Lineages of dendritic cells.jpg|thumb|right|300px|Diagram showing the 2 Lineages of dendritic cells - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]

*There are two different lineages of dendritic cells:

There are two different lineages of dendritic cells:

**From myeloid precursor cells

*From myeloid precursor cells

**From plasmacytoid precursor cells

*From plasmacytoid precursor cells

*Stimulate a primary T cell response

Dendritic cells stimulate a primary T cell response; they migrate through tissues, track to T cell dependent areas of the [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and cluster with the T cells. Dendritic cells have unique capabilities to take up antigen by pathways involving phagocytosis, macropinocytosis and clathrin-coated pits. The cell-surface antigen phenotype distinguishes the dendritic cell from [[Monocytes]]/macrophages and [[B cells]]. Their main function is priming of T helper cells.

*Migrate through tissues, track to [[T cells|T cells]]  dependent areas of [[Lymph Nodes - Anatomy & Physiology|lymph node]] and cluster with [[T cells|T cells]]

*Dendritic cells have unique capabilities to take up antigen by pathways involving phagocytosis, macropinocytosis and clathrin-coated pits

*Cell-surface antigen phenotype distinguishing it from [[Monocytes]]/macrophages and [[B cells]]

*Main function is priming of [[T cells|T helper cells]]

*Produces [[Cytokines#Chemokines|chemokines]]

*Produces [[Cytokines#Chemokines|chemokines]]