<p>In the paracortex region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] binding to [[Major_Histocompatability_Complexes#MHC_II|MHC II]] in the presence of Il-4 produced by the [[Lymphocytes#Helper CD4+|CD4<sup>+</sup> T cells]] (Th2 type) causes the B cells to differentiate; most will become plasma cells, however small number become memory cells.</p> | <p>In the paracortex region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] binding to [[Major_Histocompatability_Complexes#MHC_II|MHC II]] in the presence of Il-4 produced by the [[Lymphocytes#Helper CD4+|CD4<sup>+</sup> T cells]] (Th2 type) causes the B cells to differentiate; most will become plasma cells, however small number become memory cells.</p> |