Changes

==Plasma cells==

==Plasma cells==

===Appearance===

===Appearance===

<p>Plasma cells are oval, around 9µm and have a round prominent nucleus. The cytoplasm is extensive and stains strongly basophilic. It contains large amounts of rough endoplasmic reticulum and the Golgi apparatus is large and appears as a clear crescent-shaped structure near the nucleus. Some plasma cells accumulate considerable quantities of, perhaps abnormal, antibody and this appears as a large eosinophilic blob filling the cytoplasm and displacing the nucleus to one side. These blobs are called "Russell Bodies".</p>

<p>Plasma cells are oval, around 9µm and have a round prominent nucleus. The cytoplasm is extensive and strongly basophilic when stained. It contains large amounts of rough endoplasmic reticulum and the Golgi apparatus is large and appears as a clear crescent-shaped structure near the nucleus. Some plasma cells accumulate considerable quantities of, perhaps abnormal, antibody and this appears as a large eosinophilic blob filling the cytoplasm and displacing the nucleus to one side. These blobs are called "Russell Bodies".</p>

 

===Function===

===Function===

[[Image:B-cell-Ab.jpg|thumb|right|150px|Plasma cell antibody production - B. Catchpole, RVC 2008]]

[[Image:B-cell-Ab.jpg|thumb|right|150px|Plasma cell antibody production - B. Catchpole, RVC 2008]]