Difference between revisions of "Category:Retroviridae"

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==Morphology==
 
*Fragile, enveloped RNA viruses with roughly spherical spike proteins
 
*Genome has 3 genes:
 
**''gag'': group-specific antigen coding gene, encodes capsid proteins
 
**''pol'': encodes reverse transcriptase (RT) and integrase
 
**''env'': encodes envelope spikes, and can be used in diagnosis and subunit vaccines
 
*Both ends of genome show a promoter (LTR: long terminal repeat)
 
 
==Antigenicity==
 
*Group-specific antigens (gag's) are shared by all isolates of each virus
 
**This can be exploited by diagnostic tests
 
*Lentiviruses show variation by mutation, making vaccination difficult
 
 
==Virulence and Pathogenesis==
 
*Replication involves integrating into the host cell genome:
 
**'''Uncoating''' to release RNA and RT
 
**+RNA '''transcribed''' to -DNA by RT
 
**-DNA becomes circular dsDNA and is '''integrated''' into host chromosome by integrase
 
**DNA '''codes''' for viral proteins using cellular organelles and enzymes
 
**Because of this technique, virus replication is much '''slower''', and retroviruses can remain '''latent'''
 
*Tumor production takes 2 forms:
 
**Viruses can carry oncogenes within their genome --> tumor production occurs quickly
 
**Insertion of the viral LTR switches on proto-oncogenes in the host cell genome --> tumor production can take years
 
  
  
 
[[Category:Viral Organisms]]
 
[[Category:Viral Organisms]]
 
[[Category:To_Do_-_Clinical/Viruses]]
 
[[Category:To_Do_-_Clinical/Viruses]]

Revision as of 22:31, 7 October 2010

Retroviridae

Retroviruses are persistent, non-cytopathic, systemic viruses that give rise to secondary disease, such as tumors, immune-complex disease, or immunosuppression.

Subcategories

This category has the following 3 subcategories, out of 3 total.

Pages in category "Retroviridae"

The following 4 pages are in this category, out of 4 total.