Difference between revisions of "Myxomatosis"
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Also known as '''''Rabbit Pox | Also known as '''''Rabbit Pox | ||
[[Image:Myxomatosis_rabbit_logo.jpg|200px|right|thumb|A European Rabbit afflicted by Myxomatosis Source: Wikimedia Commons; Author: Chris Bayley, 2007]] | [[Image:Myxomatosis_rabbit_logo.jpg|200px|right|thumb|A European Rabbit afflicted by Myxomatosis Source: Wikimedia Commons; Author: Chris Bayley, 2007]] | ||
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==Prevention== | ==Prevention== | ||
− | Vaccination and control of insect parasites are the most important means of disease prevention in domestic rabbits. In order to control fleas, wild rabbits should be kept away from pet rabbits and spot-on products may be used. Mosquito control can be achieved using insect repellent strips and fine mesh netting | + | Vaccination and control of insect parasites are the most important means of disease prevention in domestic rabbits. In order to control fleas, wild rabbits should be kept away from pet rabbits and spot-on products may be used. Mosquito control can be achieved using insect repellent strips and fine mesh netting. |
− | The myxomatosis vaccine currently used in the UK is a live vaccine containing ''Shope fibroma'' virus (Nobivac Myxo, Intervet) | + | The myxomatosis vaccine currently used in the UK is a live vaccine containing ''Shope fibroma'' virus (Nobivac Myxo, Intervet). Antibodies made against ''Shope fibroma'' provide cross immunity against myxomatosis. Intradermal vaccination is performed in order to achieve adequate immunity and annual booster vaccination is recommended. Live attenuated vaccines have been used elsewhere in Europe but have been associated with other side effects such as immunosuppression. |
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==Treatment== | ==Treatment== | ||
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In-contact rabbits might not be actually incubating the disease as they might not be infected yet and therefore the vaccine has a better chance of working. If they are already incubating the disease the vaccine won’t work so there is definitely no benefit if clinical signs are established and no point using it as a therapy. | In-contact rabbits might not be actually incubating the disease as they might not be infected yet and therefore the vaccine has a better chance of working. If they are already incubating the disease the vaccine won’t work so there is definitely no benefit if clinical signs are established and no point using it as a therapy. | ||
− | + | ==Literature Search== | |
− | | | + | [[File:CABI logo.jpg|left|90px]] |
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+ | Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation). | ||
+ | <br><br><br> | ||
+ | [http://www.cabdirect.org/search.html?q=%28%28title%3A%28%22myxoma+virus%22%29%29%29+OR+%28%28title%3A%28%22myxomatosis%22%29%29%29&fq=sc%3A%22ve%22 Myxomatosis publications] | ||
==References== | ==References== | ||
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*Harcourt-Brown, F. (2002) '''Textbook of Rabbit Medicine''' ''Elsevier Health Sciences'' | *Harcourt-Brown, F. (2002) '''Textbook of Rabbit Medicine''' ''Elsevier Health Sciences'' | ||
*Kayne, S. B., Jepson, M. H. (2004) '''Veterinary Pharmacy''' ''Pharmaceutical Press'' | *Kayne, S. B., Jepson, M. H. (2004) '''Veterinary Pharmacy''' ''Pharmaceutical Press'' | ||
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+ | [[Category:Leporipoxviruses]][[Category:Rabbit Viruses]] | ||
− | + | [[Category:To_Do_-_SophieIgnarski]] | |
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Revision as of 11:23, 14 October 2010
Also known as Rabbit Pox
Introduction
Myxomatosis is a highly contagious viral condition of rabbits caused by the myxoma virus, a member of the poxvirus group. It was first recognised in the UK in 1953 after it crossed the channel from France where it was illegally introduced in 1952. It is carried mainly by arthropods, particularly the rabbit flea, Spilopsyllus cuniculi. The disease is also transmitted by direct or indirect contact with ocular or skin discharges or by mechanical vectors. The disease is characterised by subcutaneous mucinous lesions and nodular tumours and is associated with a high mortality rate.
Myxomatosis is enzootic in cottontail rabbits of the genus Sylvilagus in both South and North America and in wild rabbits of the genus Oryctolagus in South America, Europe, and Australia. All other animals are resistant to the disease.
Pathogenesis
The myxoma virus infects several cell types including mucosal cells, lymphocytes and fibroblasts. In addition to primary and secondary tumour development, there is severe immunosuppression leading to overwhelming infections by opportunistic gram-negative bacteria particularly affecting the conjunctiva and nasal passages.
Virus multiplication and tumour-like lesions occur initially at the site of intradermal inoculation. This is followed by spread to regional lymph nodes and cell-associated viraemia, with generalization to the skin and internal organs. Gelatinous proliferative nodules develop all over the body, especially at orifices such as the eyes, anus, nose. There are three known forms of disease manifestation:
- Acute Form: this becomes apparent three days after experimental infection: oedema of the head, eyelids and genitals, followed by the appearance of myxomes. This form is usually fatal and death occurs wihtin 14 days (Okerman 1994).
- The chronic, nodular form shows oedematous swellings called pseudotumours which develop after 10-15 days on the ears, nose and paws and is not so fatal (<50%) but mean survival time is 40 days (Okerman 1994). Lesions develop into hard scabs which heal into scars and sometimes can even lead to holes “punched” through the pinnae. This is the form that occurs in vaccinated animals may be worth treating in pet rabbits – oxytetracycline (Engemycin 5%®; Intervet) SC q 72hrs, good feeding and prokinetics if the gastrointestinal system seems compromised.
- A specialised form is seen in Angoras which have been vaccinated and then depilated: Lesions can be found on the torso only in animals with waning immunity after vaccination and are considered to be a type IV hypersensitivity reaction (Ganiere et al 1990).
Epidemiology
The disease is transmitted by both direct and indirect means (Okerman 1994), the former principally involving contact with infected wild rabbits; the latter, with arthropod vectors, including fleas, lice and mosquitoes, although (Gaguere 1995) implied that the mosquito is the only vector worth considering. The incubation period of the virus is two to eight days, and the duration of illness is usually from eleven to eighteen days. Pyrexia (42ºC) is a feature of the disease at or around the second day. Death is inevitable and is usually due to secondary infection with Pasteurella spp (Harkness and Wagner 1989) which is also why some cases seem to respond initially to antibiosis.
Clinical signs
The clinical disease varies with the virus strain and host species. Lepus species (hares are highly resistant; occasional individuals develop mild to severe generalized myxomatosis. Sylvilagus species are relatively resistant and are probably the natural host of the virus. In this species, infection usually results in the development of skin tumours at the site of innoculation. The tumours appear 4-8 days after exposure and persist for up to 40 days.
In the European rabbit (Oryctolagus cuniculus), infection with a virulent virus (i.e. the South American or California strains) results in severe disease with up to a 99% case fatality rate. Initial signs include oedema of the eyelids accompanied by inflammation and oedema of the anal, genital, oral and nasal orifices. Oedema of the head and ears, drooping ears and bacterial infections resulting in mucopurulent conjunctivitis and pneumonia are seen. Severe pyrexia is frequently reported. Death (8-15 days post infection) is usually preceded by dyspnoea and seizures. The mortality rate is affected by environmental temperature, with the disease being more lethal at low temperatures.
Pathology
The most prominent gross lesions in European rabbits with myxomatosis are the skin tumours and the pronounced cutaneous and subcutaneous oedema, particularly in the area of the face and around body orifices. Skin hemorrhages and subserosal petechiae and ecchymoses may be observed in the stomach and intestines. Subepicardial and subendocardial hemorrhages may also occur.
Adult rabbits of the genus Sylvilagus usually develop localized skin tumours resembling fibromas. Hares or young Sylvilagus rabbits may develop fibromatous to myxomatous nodules, however, lesions are usually mild and localized.
Prevention
Vaccination and control of insect parasites are the most important means of disease prevention in domestic rabbits. In order to control fleas, wild rabbits should be kept away from pet rabbits and spot-on products may be used. Mosquito control can be achieved using insect repellent strips and fine mesh netting.
The myxomatosis vaccine currently used in the UK is a live vaccine containing Shope fibroma virus (Nobivac Myxo, Intervet). Antibodies made against Shope fibroma provide cross immunity against myxomatosis. Intradermal vaccination is performed in order to achieve adequate immunity and annual booster vaccination is recommended. Live attenuated vaccines have been used elsewhere in Europe but have been associated with other side effects such as immunosuppression.
Treatment
Although the mortality rate in affected rabbits is high, recovery is possible and treatment can be worthwhile:
- Increase ambient temperature to 29.5°C - the virus is more virulent at lower ambient temps
- Antibiotics that combat pasteurellosis, procaine penicillin (SC q 3-4d) or oxytetyracycline (SC q72h)
- “Good nursing“
- pro-kinetics if you can get them
- NSAID's
There are anecdotal reports of the use of Interferon in myxomatosis - some cases recovered and some didn't. Did the ones that recovered receive the dose prior to clinical signs? How would you know that the rabbits were going to get the disease? Were they going to recover anyway, in spite of treatment? Rabbits that had full-blown clinical signs didn't recover, even when given Interferon. There were, apparently, no bad side-effects as a result of administration of interferon and clients might appreciate that the clinician was doing his best to help sick or in-contact rabbits.
Myxomatosis is spread rather erratically by contagion, more by vectors, so the use of “preventative treatments” (interferon or vaccination) in the face of an outbreak is difficult to justify.
In-contact rabbits might not be actually incubating the disease as they might not be infected yet and therefore the vaccine has a better chance of working. If they are already incubating the disease the vaccine won’t work so there is definitely no benefit if clinical signs are established and no point using it as a therapy.
Literature Search
Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
Myxomatosis publications
References
- Fraser, S. G. (2009) Rabbit Medicine and Surgery for Veterinary Nurses Wiley-Blackwell
- Harcourt-Brown, F. (2002) Textbook of Rabbit Medicine Elsevier Health Sciences
- Kayne, S. B., Jepson, M. H. (2004) Veterinary Pharmacy Pharmaceutical Press