Difference between revisions of "Permethrin Toxicity"
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==Introduction== | ==Introduction== | ||
| − | Permethrin is the active ingredient of many 'spot-on' | + | Permethrin is the active ingredient of many 'spot-on' paraciticides used in the control of fleas and ticks in dogs <ref> '''Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London''', ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>. |
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==Signalment== | ==Signalment== | ||
Permethrin poisoning in most commonly seen in cats who have inadvertently been administered spot-on products intended for use in dogs, or who have had contact with dogs following application of the preparations <ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>. | Permethrin poisoning in most commonly seen in cats who have inadvertently been administered spot-on products intended for use in dogs, or who have had contact with dogs following application of the preparations <ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>. | ||
==Diagnosis== | ==Diagnosis== | ||
===Clinical Signs=== | ===Clinical Signs=== | ||
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===Laboratory Tests=== | ===Laboratory Tests=== | ||
===Pathology=== | ===Pathology=== | ||
| − | The spot-on canine preparations are often quite concentrated.<ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>. Cats lack the enzyme glucuronidase transferase <ref | + | The spot-on canine preparations are often quite concentrated.<ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>. Cats lack the enzyme glucuronidase transferase <ref> Whittem 1995 Pyrethrin and pyrethroid insecticide intoxication in cats.''Compendium of Continuing Education for the Veterinary Practitioner'' '''17''' 489-492, referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> and is therefore unable to utilise the metabolic pathway that dogs and other animals use to break down permethrin into glucuronides and sulphates <re> Ray DE (1991)pesticides derived from plants and other organisms. In: Hayes WJ, Laws ER (eds), ''Handbook of Pesticide Toxicity, Classes of Pesticides''referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> |
==Treatment== | ==Treatment== | ||
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==Prognosis== | ==Prognosis== | ||
==References== | ==References== | ||
<references/> | <references/> | ||
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Revision as of 20:15, 8 November 2010
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This article is still under construction. |
Introduction
Permethrin is the active ingredient of many 'spot-on' paraciticides used in the control of fleas and ticks in dogs [1].
Signalment
Permethrin poisoning in most commonly seen in cats who have inadvertently been administered spot-on products intended for use in dogs, or who have had contact with dogs following application of the preparations [2].
Diagnosis
Clinical Signs
Laboratory Tests
Pathology
The spot-on canine preparations are often quite concentrated.[2]. Cats lack the enzyme glucuronidase transferase [3] and is therefore unable to utilise the metabolic pathway that dogs and other animals use to break down permethrin into glucuronides and sulphates <re> Ray DE (1991)pesticides derived from plants and other organisms. In: Hayes WJ, Laws ER (eds), Handbook of Pesticide Toxicity, Classes of Pesticidesreferenced in Journal of Feline Medicine and Surgery(2007)9,335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>
Treatment
Prognosis
References
- ↑ Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London, Journal of Feline Medicine and Surgery(2007)9,335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010
- ↑ 2.0 2.1 BSAVA Manual of Canine and Feline Emergency and Critical Care, Chapter 19, Second Edition, 2007
- ↑ Whittem 1995 Pyrethrin and pyrethroid insecticide intoxication in cats.Compendium of Continuing Education for the Veterinary Practitioner 17 489-492, referenced in Journal of Feline Medicine and Surgery(2007)9,335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010