Difference between revisions of "Bovine Immunodeficiency Virus"

Revision as of 13:32, 16 November 2010

Description

Bovine Imunodeficiency Virus (BIV) is a Lentivirus (non-oncogenic), a genus of the Retroviridae family. It causes a persistent viral infection in cattle worldwide and was first isolated in 1969 from a cow with a wasting syndrome. BIV causes a persistent viral infection in cattle, and has been reported in the US, Canada,Europe, Pakistan, Korea, Japan, New Zealand, Australia and several other countries. The virus is morphologically, antigenetically and genetically related to HIV.

Pathogenesis

The mechanism of transfer is not well known,but the following possibilites are being researched :

Transplacental
Transmammary
Vertical transfer through infected Semen (e.g. Artificial insemination)

Clinical Signs

The virus was originally isolated in 1969 from an 8 year old Holstein cow in the US with lymphocytosis and lymphadenopathy. Bovine immunodeficiency Virus has been associated with the folowing signs:

Decreased milk yield
Clinical immunodeficiency
Encephalitis
Bovine paraplegic syndrome
Skin infections
Emaciation

Immunocompromised cattle, arising from BIV infection, can develop secondary diseases associated with stress (e.g. parturition or environmental conditions) or sytemic disease. It may also be responsible for a poor antibody response to viral vaccines in calves.

Diagnosis

There are difficulties in the isolation of BIV from clincial cases. Serological tests such as immunoflorescence and western blot have ben used to identify the virus although virus isolation from these cases has been unsuccessful. Diagnosis by PCR remains the most sensitive test at present.

Treatment and Control

The Incidence of Bovine immunodeficiency virus appears to be low (1%) although can reach >15 % in some herds. Due to the unkown prevelance of the virus in most herds, prevention and control methods are not widely practiced. Treatment is symptomatic.

References

Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial
Quinn, P.J., Markey, B.K., Carter, M.E., Donnelly, W.J., Leonard, F.C. (2007) Veterinary Microbiology and Microbial Disease Blackwell Publishing
Marie-Claude St-Louis, Mihaela Cojocariu and Denis Archambault (2004). The molecular biology of bovine immunodeficiency virus: a comparison with other lentiviruses. Animal Health Research Reviews 5, pp 125-143

@@ Line 1: / Line 1: @@
-==Introduction==
+{{Unfinished}}
-Bovine Imunodeficiency Virus (BIV) is a [[:Category:Lentiviruses|Lentivirus]] (non-oncogenic), a genus of the [[:Category:Retroviridae|''Retroviridae'' family]]. BIV causes a persistent viral infection in cattle, and has been reported in the US, Canada,Europe, Pakistan, Korea, Japan, New Zealand, Australia and several other countries. The virus is morphologically, antigenetically and genetically related to HIV. It was first isolated in 1969 from a cow with a wasting syndrome.
+==Description==
+Bovine Imunodeficiency Virus (BIV) is a Lentivirus (non-oncogenic), a genus of the ''Retroviridae'' family. It causes a persistent viral infection in cattle worldwide and was first isolated in 1969 from a cow with a wasting syndrome. BIV causes a persistent viral infection in cattle, and has been reported in the US, Canada,Europe, Pakistan, Korea, Japan, New Zealand, Australia
+and several other countries. The virus is morphologically, antigenetically and genetically related to HIV.
 ==Pathogenesis==
-BIV has a broad cell tropism and causes a mild lymphoproliferative disorder with low viral titres and no reproducible disease sequelae. As a lentivirus it is able to integrate into the host genome and replicate within macrophages. It is associated with a long incubation period. The mechanism of transfer is not well known,but the following possibilities are being researched :
+The mechanism of transfer is not well known,but the following possibilites are being researched :
 * Transplacental
 * Transmammary
-* Vertical transfer through infected semen (e.g. artificial insemination)
+* Vertical transfer through infected Semen (e.g. Artificial insemination)
 ==Clinical Signs==
 The virus was originally isolated in 1969 from an 8 year old Holstein cow in the US with lymphocytosis and lymphadenopathy.
-Bovine immunodeficiency Virus has been associated with the following signs:
+Bovine immunodeficiency Virus has been associated with the folowing signs:
 * Decreased milk yield
 * Clinical immunodeficiency
@@ Line 17: / Line 18: @@
 * Skin infections
 * Emaciation
-Immunocompromised cattle, arising from BIV infection, can develop secondary diseases associated with stress (e.g. parturition or environmental conditions) or systemic disease. It may also be responsible for a poor antibody response to viral vaccines in calves.
+Immunocompromised cattle, arising from BIV infection, can develop secondary diseases associated with stress (e.g. parturition or environmental conditions) or sytemic disease. It may also be responsible for a poor antibody response to viral vaccines in calves.
 ==Diagnosis==
-There are difficulties in the isolation of BIV from clinical cases. Serological tests such as [[immunofluorescence]] and [[western blot]] have been used to identify the virus although virus isolation from these cases has been unsuccessful. Diagnosis by '''PCR''' remains the most sensitive test at present.
+There are difficulties in the isolation of BIV from clincial cases. Serological tests such as immunoflorescence and western blot have ben used to identify the virus although virus isolation from these cases has been unsuccessful. Diagnosis by PCR remains the most sensitive test at present.
 ==Treatment and Control==
-The Incidence of Bovine immunodeficiency virus appears to be low (1%) although can reach >15 % in some herds. Due to the unknown prevalence of the virus in most herds, prevention and control methods are not widely practiced. Treatment is symptomatic.
+The Incidence of Bovine immunodeficiency virus appears to be low (1%) although can reach >15 % in some herds. Due to the unkown prevelance of the virus in most herds, prevention and control methods are not widely practiced. Treatment is symptomatic.
-==Literature Search==
-[[File:CABI logo.jpg|left|90px]]
-Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
-<br><br><br>
-[http://www.cabdirect.org/search.html?q=title:(%22Bovine+Immunodeficiency+Virus%22) Bovine Immunodeficiency Virus publications]
 ==References==
 * Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''
 * Quinn, P.J., Markey, B.K., Carter, M.E., Donnelly, W.J., Leonard, F.C. (2007) '''Veterinary Microbiology and Microbial Disease''' ''Blackwell Publishing''
-*Marie-Claude St-Louis, Mihaela Cojocariu and Denis Archambault (2004). '''The molecular biology of bovine immunodeficiency virus: a comparison with other lentiviruses. '''''Animal Health Research Reviews'' 5, pp 125-143
+*Marie-Claude St-Louis, Mihaela Cojocariu and Denis Archambault (2004). The molecular biology of bovine immunodeficiency virus: a comparison with other lentiviruses. '''Animal Health Research Reviews''' 5, pp 125-143
-*Walder R, Kalvatchev Z, Tobin GJ, Barrios MN, Garzaro DJ, Gonda MA. (1995).''' Possible role of bovine immunodeficiency virus in bovine paraplegic syndrome: evidence from immunochemical, virological and seroprevalence studies.'''''Research in Virology'' 146(5) pp 313-23.
-{{review}}
+[[Category:Secondary Immunodeficiency]][[Category:Cattle]][[Category:To_Do_-_Review]]
-[[Category:Secondary Immunodeficiency]][[Category:Immunological Diseases - Cattle]][[Category:Neurological Diseases - Cattle]][[Category:Cattle Viruses]][[Category:Lentiviruses]][[Category:Brian Aldridge reviewing]]