Difference between revisions of "Pulmonary Infiltration with Eosinophilia"
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| − | Also known as : '''''PIE | + | |
| + | Also known as : '''''PIE - Eosinophillic Lung disease''''' | ||
==Introduction== | ==Introduction== | ||
| − | Pulmonary Infiltration with Eosinophilia (PIE) is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the | + | Pulmonary Infiltration with Eosinophilia (PIE) is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the eosinophil. It is thought to be an immune mediated condition where the airway abnormalities are a consequence of a hypersensitivity reaction to an unidentified allergen such as microfilariae of heartworms, lungworms, chronic bacterial or fungal infections (eg, histoplasmosis, aspergillosis), viruses, external antigens, and unknown precipitating factors. |
| − | '''Eosinophillic pulmonary granulomatosis''' is a severe type of PIE seen in dogs and is | + | <br> '''Eosinophillic pulmonary granulomatosis''' is a severe type of PIE seen in dogs and is characterzied by the development of nodules and hilar lymphadenopathy. It is most often associted with a hypersensitivity reaction to microfilarie in heartworm infection. |
| − | ==History & | + | ==History & Clincial signs== |
| − | Eosinophillic lung diseases are seen in young and older dogs. It is rare in the | + | Eosinophillic lung diseases are seen in young and older dogs. It is rare in the Cat. |
| − | Affected dogs usually present because of slowly progressive respiratory signs such as a cough, increased respiratory effort and exercise intolerance | + | <br> Affected dogs usually present because of slowly progressive respiratory signs such as a cough, increased respiratory effort and exercise intolerance. Systemic signs are rarely present but may include anorecia and weight loss. There may be a history of a recurring cough which is unresponsive to antibiotics but often responsive to corticosteroid therapy. The clinical signs may be seasonal in appearance. |
| − | + | ==Diagnosis== | |
| − | + | ===Physical examination=== | |
| − | ==Physical | ||
Physical examination is largely normal. Thoracic auscultation may reveal crackles or expiratory wheezes. | Physical examination is largely normal. Thoracic auscultation may reveal crackles or expiratory wheezes. | ||
| − | + | ===Radiography=== | |
| − | == | + | The most comon radiographic finding is a diffuse ''Interstitial lung pattern'', a bronchial and/or alveolar pattern may also be visible. Eosinophilic Pulmonary Granulmatosis results in the formation of nodules, usually with indistinct borders. Consolidation of lung lobs and a hilar lymphadenopathy may also be seen. |
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| − | The most | ||
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==Bronchoscopy== | ==Bronchoscopy== | ||
| − | Bronchoscopy may reveal increased amounts of mucous in the airways which may have a greenish | + | Bronchoscopy may reveal increased amounts of mucous in the airways which may have a greenish appearannce |
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| − | [[Category:Allergic Respiratory Diseases]][[Category: | + | [[Category:Allergic Respiratory Diseases]][[Category:To_Do_-_KatieB]] |
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Revision as of 16:20, 16 November 2010
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This article is still under construction. |
Also known as : PIE - Eosinophillic Lung disease
Introduction
Pulmonary Infiltration with Eosinophilia (PIE) is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the eosinophil. It is thought to be an immune mediated condition where the airway abnormalities are a consequence of a hypersensitivity reaction to an unidentified allergen such as microfilariae of heartworms, lungworms, chronic bacterial or fungal infections (eg, histoplasmosis, aspergillosis), viruses, external antigens, and unknown precipitating factors.
Eosinophillic pulmonary granulomatosis is a severe type of PIE seen in dogs and is characterzied by the development of nodules and hilar lymphadenopathy. It is most often associted with a hypersensitivity reaction to microfilarie in heartworm infection.
History & Clincial signs
Eosinophillic lung diseases are seen in young and older dogs. It is rare in the Cat.
Affected dogs usually present because of slowly progressive respiratory signs such as a cough, increased respiratory effort and exercise intolerance. Systemic signs are rarely present but may include anorecia and weight loss. There may be a history of a recurring cough which is unresponsive to antibiotics but often responsive to corticosteroid therapy. The clinical signs may be seasonal in appearance.
Diagnosis
Physical examination
Physical examination is largely normal. Thoracic auscultation may reveal crackles or expiratory wheezes.
Radiography
The most comon radiographic finding is a diffuse Interstitial lung pattern, a bronchial and/or alveolar pattern may also be visible. Eosinophilic Pulmonary Granulmatosis results in the formation of nodules, usually with indistinct borders. Consolidation of lung lobs and a hilar lymphadenopathy may also be seen.
Bronchoscopy
Bronchoscopy may reveal increased amounts of mucous in the airways which may have a greenish appearannce