Difference between revisions of "Phosphorus"
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| − | + | ==Phosphorus== | |
| − | == | ||
| − | Phosphorus is the third most | + | Phosphorus is the third most abundent intracellular ion: |
| + | #Potassium | ||
| + | #Magnesium | ||
| + | #Phosphorus (as Phosphate) | ||
| − | 1. | + | Within the body it is found as Phosphate ions or Phosphate within bone. |
| + | The majority (~95%) is combined with Calcium in bone, forming Hydroxyapatite. Less than 1% is found in the extracelullar fluid. | ||
| − | + | ==Homeostasis== | |
| − | + | Serum concentrations of phosphorus are maintained by dietary sources. It is absorbed across the intestine via ''Passive diffusion'' and ''[[Calcium#Calcitriol (Active Vitamin D3)|Vitamin D]] mediated active transport''. | |
| − | + | Phosphorus is excreted in the urine or saliva (particularly in ruminants). | |
| − | == | + | ===Hormonal Regulation=== |
| − | |||
| − | |||
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[[Calcium#Parathyroid Hormone (PTH)|'''PTH''']] | [[Calcium#Parathyroid Hormone (PTH)|'''PTH''']] | ||
| − | + | *Mobilises phosphorus from bone, acting to increase plasma concentration of P | |
| − | + | *Increases phosphorus loss in the urine and saliva, acting to decrease plasma concentration | |
| + | So ultimately, PTH acts to remove phosphorus from the body entirely. | ||
[[Calcium#Calcitriol (Active Vitamin D3)|'''Calcitriol''']] | [[Calcium#Calcitriol (Active Vitamin D3)|'''Calcitriol''']] | ||
| − | + | *Increases phosphorus absorbtion from the intestines | |
| − | |||
==Pathology== | ==Pathology== | ||
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Diseases relating to phosphorus homeostasis include: | Diseases relating to phosphorus homeostasis include: | ||
| − | + | *[[Bones Metabolic - Pathology#Primary hyperparathyroidism |Primary and Secondary Hyperparathyroidism]] | |
| − | + | *[[Kidney Renal Failure - Pathology#Uraemia |Hyperphosphataemia]] | |
| − | + | *Hypophosphatemia | |
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| + | ==Test yourself with the Phosphorus Homeostasis Flashcards== | ||
| + | [[Phosphorus_Homeostasis_Flash_Cards_- Anatomy & Physiology|Phosphorus Homeostasis Flashcards]] | ||
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[[Category:Endocrine System - Anatomy & Physiology]] | [[Category:Endocrine System - Anatomy & Physiology]] | ||
[[Category:Electrolytes]] | [[Category:Electrolytes]] | ||
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Revision as of 15:22, 29 November 2010
Phosphorus
Phosphorus is the third most abundent intracellular ion:
- Potassium
- Magnesium
- Phosphorus (as Phosphate)
Within the body it is found as Phosphate ions or Phosphate within bone. The majority (~95%) is combined with Calcium in bone, forming Hydroxyapatite. Less than 1% is found in the extracelullar fluid.
Homeostasis
Serum concentrations of phosphorus are maintained by dietary sources. It is absorbed across the intestine via Passive diffusion and Vitamin D mediated active transport.
Phosphorus is excreted in the urine or saliva (particularly in ruminants).
Hormonal Regulation
- Mobilises phosphorus from bone, acting to increase plasma concentration of P
- Increases phosphorus loss in the urine and saliva, acting to decrease plasma concentration
So ultimately, PTH acts to remove phosphorus from the body entirely.
- Increases phosphorus absorbtion from the intestines
Pathology
Diseases relating to phosphorus homeostasis include:
- Primary and Secondary Hyperparathyroidism
- Hyperphosphataemia
- Hypophosphatemia