Difference between revisions of "Bovine Herpesvirus 4"
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| − | Also Known As: '''''BHV-4 — Passenger Virus — | + | {{OpenPagesTop}} |
| + | {{Podcasts | ||
| + | |link = http://media.bloomsburymediacloud.org/podcasts/wikivet-english/bovine-herpesvirus-4}} | ||
| + | Also Known As: '''''BHV-4 — Passenger Virus — Movar Virus''''' | ||
==Introduction== | ==Introduction== | ||
| − | BHV-4 is a member of the '''''[[Herpesviridae|Herpesvirus]]''''' causing '''[[:Category:Reproductive Diseases - Cattle|reproductive disease]] in cattle in the form of [[Endometritis|endometritis]], | + | BHV-4 is a member of the '''''[[Herpesviridae|Herpesvirus]]''''' causing '''[[:Category:Reproductive Diseases - Cattle|reproductive disease]] in cattle in the form of [[Endometritis - Cattle|endometritis]], vulvovaginitis, associated abortion and [[Mastitis|mastitis]]. Most disease is however, subclinical''', hence its common name of “passenger virus”. |
The virus '''replicates within mucosal cells and then invades the mononuclear cells''', causing generalised infection and '''crossing the placenta''' to infect the unborn foetus. | The virus '''replicates within mucosal cells and then invades the mononuclear cells''', causing generalised infection and '''crossing the placenta''' to infect the unborn foetus. | ||
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==Distribution== | ==Distribution== | ||
Worldwide, although prevalence varies. | Worldwide, although prevalence varies. | ||
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In dairy cattle, BHV-4 can cause '''mastitis''' and associated udder lesions and milk changes. | In dairy cattle, BHV-4 can cause '''mastitis''' and associated udder lesions and milk changes. | ||
| − | The virus has also been isolated from cases of '''conjunctivitis and [[:Category:Respiratory Diseases - Cattle|respiratory disease]]''' but it is unclear and somewhat doubtful whether it was the responsible pathogen in these cases | + | The virus has also been isolated from cases of '''conjunctivitis and [[:Category:Respiratory Diseases - Cattle|respiratory disease]]''' in calves but it is unclear and somewhat doubtful whether it was the responsible pathogen in these cases. The respiratory route is however the main route of transmission of the virus. |
As with all [[Herpesviridae|herpesviruses]], BHV-4 can '''undergo latency, often residing in the trigeminal ganglia''' similarly to [[Infectious Bovine Rhinotracheitis|BHV-1 (IBR)]] and '''recrudescing with stress''' and/or immunosuppression. '''Recovered cattle often become latent carriers'''. Both acute and latent infections are highly prevalent in endemic BHV-4 areas. | As with all [[Herpesviridae|herpesviruses]], BHV-4 can '''undergo latency, often residing in the trigeminal ganglia''' similarly to [[Infectious Bovine Rhinotracheitis|BHV-1 (IBR)]] and '''recrudescing with stress''' and/or immunosuppression. '''Recovered cattle often become latent carriers'''. Both acute and latent infections are highly prevalent in endemic BHV-4 areas. | ||
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{{Learning | {{Learning | ||
| − | |flashcards = [[Bovine Herpesvirus-4 Flashcards|BHV- | + | |flashcards = [[Bovine Herpesvirus-4 Flashcards|BHV-4 Flashcards]] |
}} | }} | ||
==References== | ==References== | ||
<references/> | <references/> | ||
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| − | + | {{CABI source | |
| + | |datasheet = [http://www.cabi.org/ahpc/?compid=3&dsid=91720&loadmodule=datasheet&page=2144&site=160 bovine herpesvirus 4] and [http://www.cabi.org/ahpc/?compid=3&dsid=91709&loadmodule=datasheet&page=2144&site=160 bovine herpesvirus 4 infection] | ||
| + | |date = 29 July 2011 | ||
| + | }} | ||
| + | <br><br><br> | ||
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| + | {{Nick Lyons | ||
| + | |date = 1 September 2011 | ||
| + | }} | ||
| + | {{OpenPages}} | ||
| − | + | [[Category:CABI Expert Review Completed]][[Category:CABI AHPC Pages]] [[Category:Reproductive Diseases - Cattle]] [[Category:Reproductive Diseases - Sheep]][[Category:Herpesviridae]] | |
| − | [[Category:CABI Expert Review]] [[Category:Reproductive Diseases - Cattle]] [[Category:Reproductive Diseases - Sheep]] | + | [[Category:Nick Lyons reviewed]] |
Latest revision as of 12:30, 17 August 2012
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Also Known As: BHV-4 — Passenger Virus — Movar Virus
Introduction
BHV-4 is a member of the Herpesvirus causing reproductive disease in cattle in the form of endometritis, vulvovaginitis, associated abortion and mastitis. Most disease is however, subclinical, hence its common name of “passenger virus”.
The virus replicates within mucosal cells and then invades the mononuclear cells, causing generalised infection and crossing the placenta to infect the unborn foetus.
Distribution
Worldwide, although prevalence varies.
BHV-4 is transmitted directly and indirectly via infected materials containing mainly respiratory but also genital secretions from infected animals.
Signalment
A range of ruminants can be infected, including American bison, buffalo, sheep and goats.
The virus has also been isolated from lions and cats.
Clinical Signs
BHV-4 can cause abortion and births of weak or dead lambs, calves and kids. It can also increase the incidence of retained foetal membranes.
In dairy cattle, BHV-4 can cause mastitis and associated udder lesions and milk changes.
The virus has also been isolated from cases of conjunctivitis and respiratory disease in calves but it is unclear and somewhat doubtful whether it was the responsible pathogen in these cases. The respiratory route is however the main route of transmission of the virus.
As with all herpesviruses, BHV-4 can undergo latency, often residing in the trigeminal ganglia similarly to BHV-1 (IBR) and recrudescing with stress and/or immunosuppression. Recovered cattle often become latent carriers. Both acute and latent infections are highly prevalent in endemic BHV-4 areas.
Diagnosis
BHV-4 can be isolated from nasal or vaginal secretions or from triturated organs harvested from cows at necropsy.
Viral DNA can be detected by PCR.
Antibodies to BHV-4 can be detected using ELISA and Indirect Immunofluorescence. Immunoperoxidase assays are also available.
It must always be considered that presence and positive identification of BHV-4 does not mean that it is responsible for the observed disease.
Treatment
No treatment except supportive care is available. Recovered animals are often latent carriers of infection and will shed virus sporadically, providing a source of infection for others.
Control
Exclusive use of hygienic measures can gain control of BHV-4. Seropositive animals should be removed wherever possible due to the high likelihood that they are latent carriers of disease. Infected cows that calve should be isolated approaching and following parturition, as huge quantities of virus are shed in uterine exudates.
Vaccines were developed in the USA but are not widely used.
| Bovine Herpesvirus 4 Learning Resources | |
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 Test your knowledge using flashcard type questions |
BHV-4 Flashcards |
References
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This article was originally sourced from The Animal Health & Production Compendium (AHPC) published online by CABI during the OVAL Project. The datasheet was accessed on 29 July 2011. |
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This article has been expert reviewed by Nick Lyons MA VetMB CertCHP MRCVS Date reviewed: 1 September 2011 |
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