Difference between revisions of "Innate Immunity Flashcards"
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− | + | ===Actions and Tools of the Innate Immune System=== | |
− | | | + | <FlashCard questions="14"> |
− | | | + | |q1=True or False: The innate immune system responds quicker to infection than the adaptive immune system |
− | | | + | |a1=True |
− | | | + | |l1=Innate Immune System - Introduction |
− | | | + | |q2=Pathogen-associated molecular patterns (PAMPs) are expressed by which type of cells? |
− | | | + | |a2= |
− | + | *Lipopolysaccharides or Gram Negative bacteria | |
+ | *Peptidoglycans of gram-positive bacteria | ||
+ | *Mannose sugars | ||
+ | *D-isoform amino acids | ||
+ | |l2=Recognition of Microorganisms | ||
+ | |q3=What recognises PAMPs? | ||
+ | |a3=Pattern recognition receptors (PRRs) | ||
+ | |l3=Recognition of Microorganisms | ||
+ | |q4=Where in the cell are Toll-Like Receptors (TLRs) located? | ||
+ | |a4=Cell membrane | ||
+ | |l4=Recognition of Microorganisms | ||
+ | |q5=Where in the cell are NOD2 receptors located? | ||
+ | |a5=Cell cytoplasm | ||
+ | |l5=Recognition of Microorganisms | ||
+ | |q6=Which catabolic enzymes digest microbes after phagocytosis? | ||
+ | |a6= | ||
+ | *Glycosidases | ||
+ | *Lipases | ||
+ | *Proteases | ||
+ | |l6=Phagocytosis | ||
+ | |q7=True or False: Lysosomes do not use energy when they kill microbes | ||
+ | |a7= | ||
+ | *False | ||
+ | *Lysosomes fuse with phagosomes, killing microbes in an energy-dependent way | ||
+ | |l7=Phagocytosis | ||
+ | |q8=Name two physical barriers of the innate immune system | ||
+ | |a8= | ||
+ | *Skin | ||
+ | *Mucous membranes | ||
+ | |l8=Innate Immunity Barriers | ||
+ | |q9=Name 3 biochemical barriers of the innate immune system | ||
+ | |a9= | ||
+ | *Lactic and fatty acids | ||
+ | *Enzymes | ||
+ | *Mucous | ||
+ | |l9=Innate Immunity Barriers | ||
+ | |q10=What is the function of commensal organisms? | ||
+ | |a10= | ||
+ | *Produce natural antibiotics | ||
+ | *Outcompete pathogens at epithelial and mucosal surfaces | ||
+ | |l10=Innate Immunity Barriers | ||
+ | |q11=Complete the sentence about commensal organisms: | ||
+ | <p>When commensals are disturbed, infection with ??? organisms is ???</p> | ||
+ | |a11= | ||
+ | *opportunistic | ||
+ | *increased | ||
+ | |l11=Innate Immunity Barriers | ||
+ | |q12=Name the three main humoral factors and their principal action | ||
+ | |a12= | ||
+ | *Lysozyme | ||
+ | **Digests bacterial cell walls | ||
+ | *Complement | ||
+ | **Promotes phagocytosis or lysis of invading organisms | ||
+ | *Interferons | ||
+ | **Make uninfected cells resistant to infection and enhances expression of MHC molecules | ||
+ | |l12=Humoral Factors of Innate Immune System | ||
+ | |q13=Which granulocytes are components of the innate immune response to infection? | ||
+ | |a13= | ||
+ | *Neutrophils | ||
+ | *Eosinophils | ||
+ | *Basophils/mast cells | ||
+ | |l13=Innate Immunity Cellular Responses | ||
+ | |q14=Which other cells are components of the innate immune response to infection? | ||
+ | |a14=Monocytes | ||
+ | *Tissue mast cells | ||
+ | *Macrophages | ||
+ | |l14=Innate Immunity Cellular Responses | ||
+ | </FlashCard> | ||
+ | ===Innate Immunity to Viruses=== | ||
+ | <FlashCard questions="4"> | ||
+ | |q1=What is the main element of a viral attack which the innate immune system can recognise? | ||
+ | |a1=Double stranded RNA (dsRNA) | ||
+ | |l1=Innate Immunity to Viruses | ||
+ | |q2=Where are TLR3's located in the cell and what do they recognise? | ||
+ | |a2= | ||
+ | *Cell surface | ||
+ | *Double stranded RNA (dsRNA) | ||
+ | |l2=Innate Immunity to Viruses | ||
+ | |q3=What are the funtions of Type I Interferon production in response to a viral attack? | ||
+ | |a3= | ||
+ | *Increases mRNA degredation | ||
+ | *Inhibits protein synthesis | ||
+ | *Increases antigen presentation to antibody | ||
+ | |l3=Innate Immunity to Viruses | ||
+ | |q4=Which cells are produced as the final line of response to viral attack and which cells do they target? | ||
+ | |a4= | ||
+ | *Natural Killer cells (NK cells) | ||
+ | *Targets cells with decreased levels of MHC on their surface | ||
+ | |l4=Innate Immunity to Viruses | ||
+ | </FlashCard> | ||
+ | ===Innate Immunity to Bacteria=== | ||
+ | <FlashCard questions="2"> | ||
+ | |q1=What effects does the release of inflammatory cytokines have on the infected area? | ||
+ | |a1= | ||
+ | *White blood cell influx | ||
+ | *Vasodilation | ||
+ | *Increase in vascular permeability | ||
+ | *Sustains a rise in core temperature | ||
+ | *Mediates the release of acute phase proteins from the liver | ||
+ | *Mediates bone marrow mobilisation | ||
+ | |l1=Innate Immunity to Bacteria | ||
+ | |q2=Which cell is the most important effector cell in the innate response to bacterial infection? | ||
+ | |a2=Neutrophils | ||
+ | |l2=Innate Immunity to Bacteria | ||
+ | </FlashCard> | ||
− | + | <br><br> | |
− | { | + | {{Jim Bee 2007}} |
− | + | [[Category:Immunology Flashcards]] | |
− | + | [[Category:Innate Immune System|Z]] | |
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Latest revision as of 09:30, 21 May 2012
Actions and Tools of the Innate Immune System
Question | Answer | Article | |
True or False: The innate immune system responds quicker to infection than the adaptive immune system | True
|
Link to Article | |
Pathogen-associated molecular patterns (PAMPs) are expressed by which type of cells? |
|
Link to Article | |
What recognises PAMPs? | Pattern recognition receptors (PRRs)
|
Link to Article | |
Where in the cell are Toll-Like Receptors (TLRs) located? | Cell membrane
|
Link to Article | |
Where in the cell are NOD2 receptors located? | Cell cytoplasm
|
Link to Article | |
Which catabolic enzymes digest microbes after phagocytosis? |
|
Link to Article | |
True or False: Lysosomes do not use energy when they kill microbes |
|
Link to Article | |
Name two physical barriers of the innate immune system |
|
Link to Article | |
Name 3 biochemical barriers of the innate immune system |
|
Link to Article | |
What is the function of commensal organisms? |
|
Link to Article | |
Complete the sentence about commensal organisms:
When commensals are disturbed, infection with ??? organisms is ??? |
|
Link to Article | |
Name the three main humoral factors and their principal action |
|
Link to Article | |
Which granulocytes are components of the innate immune response to infection? |
|
Link to Article | |
Which other cells are components of the innate immune response to infection? | Monocytes
|
Link to Article |
Innate Immunity to Viruses
Question | Answer | Article | |
What is the main element of a viral attack which the innate immune system can recognise? | Double stranded RNA (dsRNA)
|
Link to Article | |
Where are TLR3's located in the cell and what do they recognise? |
|
Link to Article | |
What are the funtions of Type I Interferon production in response to a viral attack? |
|
Link to Article | |
Which cells are produced as the final line of response to viral attack and which cells do they target? |
|
Link to Article |
Innate Immunity to Bacteria
Question | Answer | Article | |
What effects does the release of inflammatory cytokines have on the infected area? |
|
Link to Article | |
Which cell is the most important effector cell in the innate response to bacterial infection? | Neutrophils
|
Link to Article |
Originally funded by the RVC Jim Bee Award 2007 |