Difference between revisions of "Complement Flashcards"
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| − | + | ===Complement Fixation Pathways=== | |
| − | | | + | <FlashCard questions="10"> |
| − | | | + | |q1=What are the names of the different pathways of the complement cascade? |
| − | | | + | |a1= |
| − | | | + | *Classical |
| − | | | + | *Alternative |
| − | | | + | *Mannose-binding Lectin |
| − | + | |l1=Complement#Compelment Fixation Pathways | |
| + | |q2=Which immunoglobulins can activate the classical pathway? | ||
| + | |a2= | ||
| + | *IgM | ||
| + | *IgG | ||
| + | |l2=Complement#Compelment Fixation Pathways | ||
| + | |q3=What are the components of the C1 complex | ||
| + | |a3= | ||
| + | *C1q | ||
| + | *C1r | ||
| + | *C1s | ||
| + | |l3=Complement#Compelment Fixation Pathways | ||
| + | |q4=Which two complexes bind to make the enzyme C3 convertase? | ||
| + | |a4= | ||
| + | *C2a | ||
| + | *C4b | ||
| + | |l4=Complement#Compelment Fixation Pathways | ||
| + | |q5=What initiates the membrane attack complex (MAC)? | ||
| + | |a5=C3b | ||
| + | |l5=Complement#Compelment Fixation Pathways | ||
| + | |q6=What functions do the C fragments C3a, C4a, C5a and C2b have? | ||
| + | |a6= | ||
| + | *Chemotactic for neutrophils | ||
| + | *Induces acute inflammation | ||
| + | *Increases vascular permeability | ||
| + | *Causes mast cell and basophil degranulation | ||
| + | |l6=Complement#Compelment Fixation Pathways | ||
| + | |q7=What are efficient activators of the alternative pathway? | ||
| + | |a7= | ||
| + | *Gram-negative bacteria | ||
| + | *Yeasts | ||
| + | *Fungi | ||
| + | |l7=Complement#Alternative Pathway | ||
| + | |q8=What are the main functions of the alternative pathway? | ||
| + | |a8= | ||
| + | *To coat bacteria with iC3b | ||
| + | *To induce an acute inflammatory response | ||
| + | |l8=Complement#Alternative Pathway | ||
| + | |q9=What are lectins? | ||
| + | |a9=Proteins which bind carbohydrates | ||
| + | |l9=Complement#MB-Lectin Pathway | ||
| + | |q10=What does MASP stand for? | ||
| + | |a10=Mannose-binding lectin associated proteases | ||
| + | |l10=Complement#MB-Lectin Pathway | ||
| + | </FlashCard> | ||
| − | == | + | ===Complement Inhibitors=== |
| − | + | <FlashCard questions="4"> | |
| − | + | |q1=Which complement inhibitor exorts control over the classical pathway and how does it function? | |
| − | + | |a1= | |
| − | + | *Delay acclerating factor (DAF) | |
| − | + | **Increases the degredation of C1 esterase | |
| − | + | |l1=Complement#Complement Inhibitors | |
| − | + | |q2=What do factors I and H do? | |
| − | + | |a2= | |
| − | + | *Breaks down C3b | |
| − | + | *Controls positive feedback by inhibiting C3b¯Bb | |
| − | + | *Prevents the complement cascade from running to exhaustion every time it is activated | |
| − | + | |l2=Complement#Complement Inhibitors | |
| − | + | |q3=Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis? | |
| − | + | |a3=Complement receptor 1 (CR1) | |
| − | + | |l3=Complement#Complement Inhibitors | |
| − | + | |q4=What does CD59 do? | |
| − | + | |a4= | |
| − | + | *Prevents cell lysis and pore formation | |
| − | + | *It is a protective mechanism for cells | |
| − | + | |l4=Complement#Complement Inhibitors | |
| − | + | </FlashCard> | |
| − | + | ===Functions of the Complement Cascade=== | |
| − | + | <FlashCard questions="3"> | |
| − | + | |q1=What are the stages of opsonisation? | |
| − | + | |a1= | |
| − | + | *The complement system deposits a shell of protein on the bacterial cell surface, e.g. complement fragments | |
| − | + | *Complement fragments released are chemotactic for phagocytes | |
| − | + | *iC3b acts as a target for phagocytosis | |
| − | + | *Phagocytes bind with the complement fragments destroying the bacteria | |
| − | + | |l1=Complement#Functions | |
| − | + | |q2=What role do complement fragments have to promote inflammation? | |
| − | + | |a2= | |
| − | + | *Smaller complement fragments attract granulocytes to the site of inflammation | |
| − | + | *Smaller complement fragments stimulate the degranulation of granulocytes | |
| − | + | |l2=Complement#Functions | |
| − | + | |q3=By which process can C5-C9 directly kill pathogens? | |
| − | + | |a3=Cell lysis | |
| − | + | |l3=Complement#Functions | |
| − | + | </FlashCard> | |
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| − | + | <br><br> | |
| − | { | + | {{Jim Bee 2007}} |
| − | + | [[Category:Immunology Flashcards]] | |
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Latest revision as of 08:20, 24 May 2012
Complement Fixation Pathways
| Question | Answer | Article | |
| What are the names of the different pathways of the complement cascade? |
|
Link to Article | |
| Which immunoglobulins can activate the classical pathway? |
|
Link to Article | |
| What are the components of the C1 complex |
|
Link to Article | |
| Which two complexes bind to make the enzyme C3 convertase? |
|
Link to Article | |
| What initiates the membrane attack complex (MAC)? | C3b
|
Link to Article | |
| What functions do the C fragments C3a, C4a, C5a and C2b have? |
|
Link to Article | |
| What are efficient activators of the alternative pathway? |
|
Link to Article | |
| What are the main functions of the alternative pathway? |
|
Link to Article | |
| What are lectins? | Proteins which bind carbohydrates
|
Link to Article | |
| What does MASP stand for? | Mannose-binding lectin associated proteases
|
Link to Article | |
Complement Inhibitors
| Question | Answer | Article | |
| Which complement inhibitor exorts control over the classical pathway and how does it function? |
|
Link to Article | |
| What do factors I and H do? |
|
Link to Article | |
| Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis? | Complement receptor 1 (CR1)
|
Link to Article | |
| What does CD59 do? |
|
Link to Article | |
Functions of the Complement Cascade
| Question | Answer | Article | |
| What are the stages of opsonisation? |
|
Link to Article | |
| What role do complement fragments have to promote inflammation? |
|
Link to Article | |
| By which process can C5-C9 directly kill pathogens? | Cell lysis
|
Link to Article | |
|
Originally funded by the RVC Jim Bee Award 2007 |