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| − | {{review}}
| + | #redirect[[:Category:Integumentary System - Viral Infections]] |
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| − | {{toplink
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| − | |backcolour = FFCCCC
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| − | |linkpage =Integumentary System - Pathology
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| − | |linktext =Integumentary System
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| − | |maplink = Integumentary System (Content Map) - Pathology
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| − | |pagetype =Pathology
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| − | |sublink1 = Skin Infectious - Pathology
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| − | |subtext1 = SKIN INFECTIOUS
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| − | }}
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| − | <br>
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| − | ===[[Poxviruses]]===
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| − | *Lesion development:
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| − | **Due to viral invasion of epithelium
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| − | **Vascular injury -> ischaemic necrosis
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| − | **Stimulation of host DNA -> hyperplastic nodules
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| − | *Cutaneous lesions:
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| − | **[[Skin Glossary - Pathology|Macule]] -> [[Skin Glossary - Pathology|papule]] -> [[Skin Glossary - Pathology|vesicle]] -> umbilicated [[Skin Glossary - Pathology|pustule]] -> [[Skin Glossary - Pathology|crust]] -> [[Skin Glossary - Pathology|scar]]
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| − | ====Contagious ecthyma====
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| − | [[Image: Contagious ecthyma.jpg|100px|thumb|right|<small><center>Contagious ecthyma (Courtesy of Bristol BioMed Image Archive)</center></small>]]
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| − | *Also called '''contagious pustular dermatitis, orf, sore mouth'''
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| − | *Caused by a [[Poxviruses#Contagious ecthyma|parapox virus]]
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| − | *Affects mainly young sheep, less commonly cattle, humans, dogs
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| − | *Starts in abrasions around mouth commisures and spreads to [[Lips - Anatomy & Physiology|lips]], oral mucosa, eyelids and feet
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| − | *May also transfer to teats of the mother of an affected lamb
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| − | *Lesions typical of poxvirus but very brief vesicle stage
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| − | *Most obvious is the proliferative pustular stage
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| − | ===[[Herpesviridae|Herpesviruses]]===
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| − | *Cutaneous lesions may develop with nondermatotropic viruses:
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| − | **[[Respiratory Viral Infections - Pathology#Infectious bovine rhinotracheitis (IBR)|Infectious bovine rhinotracheitis]] (bovine herpes virus - 1)
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| − | **Equine coital exanthema (equine herpes virus - 3)
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| − | **[[Respiratory Viral Infections - Pathology#Feline viral rhinotracheitis|Feline herpes virus -1]] (rarely)
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| − | *Dermatotropic viruses:
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| − | **'''Bovine herpes virus - 2 = Bovine herpes mammillitis virus'''
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| − | ***May cause generalised disease - pseudolumpy skin
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| − | ***Localised disease - bovine herpes mammillitis
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| − | ****Mostly in lactating cows
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| − | ****Skin trauma is essential for virus invasion
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| − | ****Decreased milk production and secondary bacterial mastitis
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| − | ****Lesion occur on teats, udder, sometimes perineum, on muzzle of suckling calves
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| − | **'''Bovine herpes virus - 4 = Bovine herpes mammary pustular dermatitis'''
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| − | ***Similar to localised BHV-2 but milder disease
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| − | *May be latent and reappear at times of stress
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| − | *Grossly:
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| − | **[[Skin Glossary - Pathology|Vesicles, ulcers, crusts]]
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| − | *Microscopically:
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| − | **Intraepidermal vesicle
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| − | **Epidermal cell degeneration
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| − | **[[Skin Glossary - Pathology|Acantholysis]]
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| − | **Syncytial cells may form
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| − | **Intracellular inclusion bodies may be found at edges of ulcers
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| − | **Rapid necrosis
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| − | ===Other viruses===
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| − | *Cutaneous lesion are seen with:
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| − | **[[Picornaviridae]]
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| − | ***[[Cavity & Gingiva - Pathology#Foot and Mouth disease|Foot-and-mouth disease]]
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| − | ***[[Cavity & Gingiva - Pathology#Swine Vesicular Disease|Swine vesicular disease]]
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| − | **[[Rhabdoviridae]]
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| − | ***Vesicular stomatitis
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| − | **[[Caliciviridae]]
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| − | ***Vesicular exanthema
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| − | **[[Retroviridae]]
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| − | ***'''Feline leukemia virus'''
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| − | ****Cutaneous horns on foot pads
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| − | ****Epidermal and follicular epithelial hyperplasia, epidermal giant cells, dyskeratosis, necrosis, ulceration
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| − | ***'''Feline immunodeficiency virus'''
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