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− | ===Hyperplastic===
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− | ====[[Polychlorinated Napthalene Poisoning]]====
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− | ===Papular===
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− | ====Orf====
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− | *[[Poxviridae|Pox]] infection
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− | *Quite a common '''zoonotic''' disease
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− | Papular proliferative pathology
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− | =====Clinical=====
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− | *In sheep produces a proliferative nodule/papular mass on [[Lips - Anatomy & Physiology|lips]]
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− | *In flocks in which it is endemic it is seen in lamb
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− | *If flock is non-immune seen in ewes too but much worse in lambs (may spread to inside of mouth)
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− | *Can spread to udder of ewe
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− | =====Pathology=====
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− | *Poxvirus infections produce local infection of [[prickle cells]] in epithelium with proliferation of cells and formation of papule followed by ulceration / necrosis and covered by necrotic epithelium
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− | *Eventually scabs form and crust drops off
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− | *Scabs - very infectious ( N.B.if touch -> catch it)
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− | ====Bovine Papular stomatitis====
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− | [[Image:BPS.gif|right|thumb|125px|<small><center>Ring Zone Lesions of BPS - Calf (Courtesy of Alun Williams (RVC))</center></small>]]
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− | *Parapox virus
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− | *Very similar disease to orf but seen in cattle and generally milder condition.
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− | *'''Must be differentiated from [[#Foot and Mouth disease|Foot and Mouth Disease]] and [[#Bovine Viral Diarrhoea / Mucosal disease|Mucosal Disease.]]'''
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− | *Sporadic, in cattle, less than 1 year old.
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− | *Develop papules on the muzzle, external nares and in the [[Oral Cavity Overview - Anatomy & Physiology|oral cavity]]; the [[Oesophagus - Anatomy & Physiology|oesophagus]] and [[Stomach and Abomasum - Anatomy & Physiology|forestomachs]] may also be affected.
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− | *Usually heals spontaneously.
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− | =====Pathogenesis=====
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− | *The early lesions are round areas of intense congestion up to 1.5 cm in diameter.
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− | *The centre becomes necrotic and slightly depressed.
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− | *Slow peripheral extension of this lesion gives a classical ring zone formation with concentric rings of
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− | **yellow (necrosis),
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− | **grey (epithelial hyperplasia)
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− | **red (congestion).
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− | =====Histology=====
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− | *There are focal areas of hydropic degeneration in the stratum spinosum
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− | *Large eosinophilic intracytoplasmic inclusion
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− | *Epidermis is markedly thickened.
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− | *The superficial layers of the epithelium become necrotic and slough.
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− | *''Vesicle formation is not a feature of this disease.''
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− | ====Papilloma====
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− | ===Neoplastic===
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− | ====Squamous cell carcinoma====
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− | [[Image:oral squamous cell carcinoma.jpg|right|thumb|125px|<small><center>'''Oral squamous cell carcinoma'''. Courtesy of T. Scase</center></small>]] neoplastic
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| [[Category:Oral_Cavity_and_Gingiva_-_Pathology]] | | [[Category:Oral_Cavity_and_Gingiva_-_Pathology]] |