Amyloid-producing Odontogenic Tumour

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Also known as: Calcifying epithelial odontogenic tumour


The lesions are slow growing and locally invasive.The most prominent feature of this type of tumour is that it produces amyloid which tends to calcify.

Typical Signalment

This is a rare tumour seen more often in cats and than in dogs.


Clinical Signs

Include halitosis, oral bleeding, dental disruption or loss, facial or mandibular deformity, excessive salivation, growth protruding from the mouth and rarely dysphagia.

Diagnostic Imaging

Skull radiography may show a soft tissue opacity with mineralization within the mass. Periosteal reaction of the adjacent bone may be visualised. If a malignant neoplasm is a diagnostic possibility, thoracic radiography should be carried out to evaluate for lung metastases.


Biopsy is required for a definitive diagnosis. Incisional biopsy is the best option, when undertaking cytological or grab procedures it is difficult to obtain a representative sample.

Histologically, the tumour appears to be well demarcated from the surrounding tissue but is not encapsulated.


Surgical excision with narrow margins is normally sufficient. Radiation therapy should be considered in cases of incomplete surgical excision.


Good following complete surgical excision however recurrance following incomplete surgical excision is possible.

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Amyloid-producing Odontogenic Tumour publications


Tutt, C., Deeprose, J. and Crossley, D. (2007) BSAVA Manual of Canine and Feline Dentistry (3rd Edition) BSAVA

Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial

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