Difference between revisions of "Category:Cardiovascular System - Developmental Pathology"

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|pagetitle =Cardiovascular System - Developmental Pathology
 
|pagetitle =Cardiovascular System - Developmental Pathology
 
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'''Introduction'''
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Congenital heart disorders are structural and/or functional abnormalities that are present at birth. These defects are the result of either inherited abnormalities or insults to the fetus in utero.  The most common conditions are listed below.
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Congenital abnormalities occur relatively commonly in young (approximately 1% all human births).  May produce dramatic clinical signs or signs may be vague, such as failure to thrive.  Clinical signs may become more apparent as the animal grows and activity levels increase.
 
Congenital abnormalities occur relatively commonly in young (approximately 1% all human births).  May produce dramatic clinical signs or signs may be vague, such as failure to thrive.  Clinical signs may become more apparent as the animal grows and activity levels increase.
  
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*Environmental; Includes infection (usually viral), chemical, nutritional and physical factors.
 
*Environmental; Includes infection (usually viral), chemical, nutritional and physical factors.
  
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Understanding the [[Developmental Anatomy of the Heart - Anatomy & Physiology|normal development of the heart and great vessels]] allows an understanding of the morphology and pathology of the congenital abnormalities seen in mammals.
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Understanding the [[Heart Development - Anatomy & Physiology|normal development of the heart and great vessels]] allows an understanding of the morphology and pathology of the congenital abnormalities seen in mammals.
 
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==Chamber Development==
 
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===[[Atrial Septal Defect]]===
 
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===[[Ventricular Septal Defect]]===
 
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===[[Patent Ductus Arteriosus]]===
 
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==Great Vessels==
 
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===[[Vascular Ring Anomaly]]===
 
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===[[Tetralogy of Fallot]]===
 
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==Valve Development==
 
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===[[Aortic Stenosis]]===
 
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===Pulmonic Stenosis===
 
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Obstructs blood flowing form the right ventricle to the pulmonary artery.  As with aortic stenosis may be subvalvular, valvular or supravalvular.  Valvular stenosis is the most common form in the dog.
 
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''Incidence:''
 
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*Increased incidence in English bulldogs, Cocker spaniels, Chihuahuas.
 
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*Autosomal dominant in Beagles.
 
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''Clinical Signs:''
 
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*Asymptomatic if mild or moderate.
 
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*If severe; exercise intolerance, stunting, syncope, right sided heart failure E.g. ascites.
 
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*Harsh systolic murmur at left heart base.
 
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*May hear splitting of the second heart sound due to delayed closure of the pulmonic valve.
 
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*Femoral pulse quality good but jugulars distended.
 
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''Diagnosis:''
 
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*Right ventricular enlargement on radiology, along with post-stenotic dilatation of the pulmonary artery and pulmonary undercirculation.
 
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*Abnormal valve can be imaged using echocardiography.
 
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*Severity of stenosis can be assessed using Doppler to calculate flow rates.
 
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''Treatment:''
 
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*Balloon valvuloplasty is treatment of choice.
 
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===Mitral Dysplasia===
 
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Often associated with mitral regurgitation and left atrial volume overload.  Usually progresses to left sided heart failure.
 
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''Incidence:''
 
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[[Image:AV valve dysplasia cat.jpg|right|thumb|200px|<small><center>'''Mitral dyplasia'''. Courtesy of A. Jefferies</center></small>]]
 
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*Most common congenital defect in cats.
 
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*Also reported in pure breed dogs E.g GSD, Great Danes.
 
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''Clinical Signs:''
 
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*Often murmur is the only clinical sign; pansystolic with increased intensity over the mitral valve area.
 
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*May also see exercise intolerance, dyspnoea and coughing.
 
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''Diagnosis:''
 
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*Left atrial enlargement on radiology and ECG.
 
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*Doppler echocardiography can dtect abnormal flow.
 
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''Treatment:''
 
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*Prognosis poor, medically manage left heart failure with ACE-inhibitors etc.
 
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===Tricuspid Dysplasia===
 
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Tricuspid regurgitation results in volume overload of the right atrium and may progress to right heart failure.<br>
 
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'''''Ebstein's Anomaly:''''' Atrioventricular ring is displaced ventrally into the right ventricle so that part of the wall of the right atrium is made up of ventricular wall.
 
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''Incidence:''
 
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*Second most common congenital anomaly seen in cats.
 
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*Also reported in large breeds of dog including Weimeraner.
 
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''Clinical Signs:''
 
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*Often the murmur is the only clinical sign; low grade and pansystolic with increased intensity over the tricuspid area.
 
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*May also see right sided failure, signs include; ascites, hepatomegaly and splenomegaly.
 
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''Diagnosis:''
 
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*Right ventricular enlargement on radiology and ECG.
 
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==Miscellaneous==
 
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===Peritoneo-pericardial Diaphragmatic Hernia===
 
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Represents an embryological malformation of the ventral midline with communication to varying degress of the pericardial sac and the [[Peritoneal cavity - Anatomy & Physiology|peritoneal cavity]].  Often associated with other malformations for example sternal deformities and [[Heart and Great Vessels Development - Pathology#Ventricular_Septal_Defect|ventricular septal defects]].
 
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Usually results in gastrointestinal or respiratory signs.
 
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Visible radiologically as a round cardiac silhouette which merges with the diaphragm.  The trachea will be displaced dorsally.  Intestines may be visible on radiographs.  Repaired surgically.
 
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===Ectopia Cordis===
 
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The heart is normal in anatomy but situated in an abnormal location within the body.  Cattle and pigs show the highest incidence.  The heart may be found in the cervical region or the abdomen.
 
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===Endocardial fibro-elastosis===
 
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Seen in Burmese kittens.  Collagen and elastin are deposited in the endocardium, limiting its function.  Animals are often found dead at 2-3 months of age.
 
 
[[Category:Cardiovascular System - Pathology]]
 
[[Category:Cardiovascular System - Pathology]]

Latest revision as of 18:45, 15 February 2011

Cardiovascular System - Developmental Pathology

Introduction Congenital heart disorders are structural and/or functional abnormalities that are present at birth. These defects are the result of either inherited abnormalities or insults to the fetus in utero. The most common conditions are listed below.

Congenital abnormalities occur relatively commonly in young (approximately 1% all human births). May produce dramatic clinical signs or signs may be vague, such as failure to thrive. Clinical signs may become more apparent as the animal grows and activity levels increase.

The aetiology of congenital defects of the heart and great vessels are mostly unknown. Possible contributing factors include:

  • Genetic; E.g. Mutation in the ova or sperm or mutation in the zygote.
  • Environmental; Includes infection (usually viral), chemical, nutritional and physical factors.

Understanding the normal development of the heart and great vessels allows an understanding of the morphology and pathology of the congenital abnormalities seen in mammals.

Content

▼ Cardiovascular System - Developmental Pathology
  Aortic Stenosis
  Arteriovenous Anastamoses
  Atrial Septal Defect
  Degenerative Mitral Valve Disease
  Ectopia Cordis
  Endocardial Fibro-Elastosis
  Hernia, Peritoneopericardial Diaphragmatic
  Patent Ductus Arteriosus
  Pulmonic Stenosis
  Tetralogy of Fallot
  Tricuspid Valve Dysplasia
  Vascular Ring Anomalies
  Ventricular Septal Defect
  Cardiovascular Developmental Pathology Flashcards

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